Addiction is a disease in which, after a period of recreational use, a subset of individuals
develops compulsive use that does not stop even in light of major negative consequences …

Opioid use kills tens of thousands of Americans each year, devastates families and entire
communities, and cripples the health care system. Exposure to opioids causes long-term …

Cocaine use disorder (CUD) is an intractable syndrome, and rising overdose death rates
represent a substantial public health crisis that exacts tremendous personal and financial …

Background Prevalence rates of opioid use disorder (OUD) have increased dramatically,
accompanied by a surge of overdose deaths. While opioid dependence has been …

Drugs of abuse elevate dopamine levels in the nucleus accumbens (NAc) and alter
transcriptional programs believed to promote long-lasting synaptic and behavioral …

Opioid use disorder (OUD) looms as one of the most severe medical crises facing society.
More effective therapeutics will require a deeper understanding of molecular changes …

Coordinated activity-induced transcriptional changes across multiple neuron subtypes of the
prefrontal cortex (PFC) play a pivotal role in encoding and regulating major cognitive …

Drugs of abuse are thought to promote addiction in part by “hijacking” brain reward systems,
but the underlying mechanisms remain undefined. Using whole-brain FOS map** and in …

The amygdala processes positive and negative valence and contributes to addiction, but the
cell-type-specific gene regulatory programs involved are unknown. We generated an atlas of …

Repeated cocaine use induces coordinated changes in gene expression that drive plasticity
in the nucleus accumbens (NAc), an important component of the brain's reward circuitry, and …