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The present and future of bispecific antibodies for cancer therapy
Bispecific antibodies (bsAbs) enable novel mechanisms of action and/or therapeutic
applications that cannot be achieved using conventional IgG-based antibodies …
applications that cannot be achieved using conventional IgG-based antibodies …
Humanized mouse models for immuno-oncology research
J Chuprin, H Buettner, MO Seedhom… - Nature Reviews …, 2023 - nature.com
Immunotherapy has emerged as a promising treatment paradigm for many malignancies
and is transforming the drug development landscape. Although immunotherapeutic agents …
and is transforming the drug development landscape. Although immunotherapeutic agents …
Challenges and new technologies in adoptive cell therapy
Adoptive cell therapies (ACTs) have existed for decades. From the initial infusion of tumor-
infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and …
infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and …
The use of RNA-based treatments in the field of cancer immunotherapy
Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …
The current landscape of CAR T-cell therapy for solid tumors: Mechanisms, research progress, challenges, and counterstrategies
The successful outcomes of chimeric antigen receptor (CAR) T-cell therapy in treating
hematologic cancers have increased the previously unprecedented excitement to use this …
hematologic cancers have increased the previously unprecedented excitement to use this …
Engineering CAR-T cells for next-generation cancer therapy
T cells engineered to express chimeric antigen receptors (CARs) with tumor specificity have
shown remarkable success in treating patients with hematologic malignancies and …
shown remarkable success in treating patients with hematologic malignancies and …
Engineering strategies to overcome the current roadblocks in CAR T cell therapy
T cells genetically engineered to express chimeric antigen receptors (CARs) have proven—
and impressive—therapeutic activity in patients with certain subtypes of B cell leukaemia or …
and impressive—therapeutic activity in patients with certain subtypes of B cell leukaemia or …
Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany
Chimeric antigen receptor (CAR)-T cell therapies are on the verge of becoming powerful
immunotherapeutic tools for combating hematological diseases confronted with pressing …
immunotherapeutic tools for combating hematological diseases confronted with pressing …
Enhancing the safety of CAR-T cell therapy: Synthetic genetic switch for spatiotemporal control
Chimeric antigen receptor T (CAR-T) cell therapy is a promising and precise targeted
therapy for cancer that has demonstrated notable potential in clinical applications. However …
therapy for cancer that has demonstrated notable potential in clinical applications. However …
Programmable synthetic receptors: the next-generation of cell and gene therapies
F Teng, T Cui, L Zhou, Q Gao, Q Zhou… - Signal Transduction and …, 2024 - nature.com
Cell and gene therapies hold tremendous promise for treating a range of difficult-to-treat
diseases. However, concerns over the safety and efficacy require to be further addressed in …
diseases. However, concerns over the safety and efficacy require to be further addressed in …