Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance
Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …
Fluorescent probes as a tool in diagnostic and drug delivery systems
Over the last few years, the development of fluorescent probes has received considerable
attention. Fluorescence signaling allows noninvasive and harmless real-time imaging with …
attention. Fluorescence signaling allows noninvasive and harmless real-time imaging with …
Hows and whys of tumor-seeking dyes
Conspectus Active targeting uses molecular fragments that bind receptors overexpressed on
cell surfaces to deliver cargoes, and this selective delivery to diseased over healthy tissue is …
cell surfaces to deliver cargoes, and this selective delivery to diseased over healthy tissue is …
Routine culture and study of adult human brain cells from neurosurgical specimens
When modeling disease in the laboratory, it is important to use clinically relevant models.
Patient-derived human brain cells grown in vitro to study and test potential treatments …
Patient-derived human brain cells grown in vitro to study and test potential treatments …
Heptamethine cyanine dye mediated drug delivery: hype or hope
This review covers the application of heptamethine cyanine dye (HMCD) mediated drug
delivery. A relatively small number of HMCDs possess tumor targeting abilities, and this has …
delivery. A relatively small number of HMCDs possess tumor targeting abilities, and this has …
Fluorescent kinase inhibitors as probes in cancer
Fluorescent dyes attached to kinase inhibitors (KIs) can be used to probe kinases in vitro, in
cells, and in vivo. Ideal characteristics of the dyes vary with their intended applications …
cells, and in vivo. Ideal characteristics of the dyes vary with their intended applications …
The use of heptamethine cyanine dyes as drug-conjugate systems in the treatment of primary and metastatic brain tumors
Effective cancer therapeutics for brain tumors must be able to cross the blood-brain barrier
(BBB) to reach the tumor in adequate quantities and overcome the resistance conferred by …
(BBB) to reach the tumor in adequate quantities and overcome the resistance conferred by …
Involvement of the tumour necrosis factor receptor system in glioblastoma cell death induced by palbociclib-heptamethine cyanine dye conjugate
Glioblastoma is the most common and aggressive primary brain tumour in adults. The
development of anti-brain cancer agents are challenged by the blood-brain barrier and the …
development of anti-brain cancer agents are challenged by the blood-brain barrier and the …
Molecular Tuning of IR-786 for Improved Tumor Imaging and Photothermal Therapy
W Lim, JY Byun, G Jo, EJ Kim, MH Park, H Hyun - Pharmaceutics, 2022 - mdpi.com
A tumor-targeted near-infrared (NIR) fluorophore CA800Cl was developed based on
commercially available IR-786 by modulating its physicochemical properties. IR-786, a …
commercially available IR-786 by modulating its physicochemical properties. IR-786, a …
Elucidating the cellular uptake mechanisms of heptamethine cyanine dye analogues for their use as an anticancer drug‐carrier molecule for the treatment of …
The development of chemotherapies for glioblastoma is hindered by their limited
bioavailability and toxicity on normal brain function. To overcome these limitations, we …
bioavailability and toxicity on normal brain function. To overcome these limitations, we …