Microglia-mediated neuroinflammation: a potential target for the treatment of cardiovascular diseases

M Wang, W Pan, Y Xu, J Zhang, J Wan… - Journal of inflammation …, 2022 - Taylor & Francis
Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS,
microglia play an important role in the monitoring and intervention of synaptic and neuron …

Fir (e) ing the rhythm: inflammatory cytokines and cardiac arrhythmias

PE Lazzerini, A Abbate, M Boutjdir… - Basic to Translational …, 2023 - jacc.org
Inflammatory activation is increasingly recognized as a nonconventional risk factor for
arrhythmias, and experimental studies provided robust evidence that this association is …

Neutrophil extracellular traps aggravate neuronal endoplasmic reticulum stress and apoptosis via TLR9 after traumatic brain injury

L Mi, X Min, M Shi, L Liu, Y Zhang, Y Zhu, P Li… - Cell death & …, 2023 - nature.com
Endoplasmic reticulum (ER) stress and ER stress-mediated apoptosis play an important role
during secondary brain damage after traumatic brain injury (TBI). Increased neutrophil …

Microglia‐Mediated Neuroimmune Response Regulates Cardiac Remodeling After Myocardial Infarction

M Wang, J Zhang, Z Yin, W Ding, M Zhao… - Journal of the …, 2023 - ahajournals.org
Background Sympathetic hyperactivity contributes to pathological remodeling after
myocardial infarction (MI). However, the mechanisms underlying the increase in sympathetic …

IL-1 signaling pathway, an important target for inflammation surrounding in myocardial infarction

J Huang, W Kuang, Z Zhou - Inflammopharmacology, 2024 - Springer
Acute myocardial infarction is an important cardiovascular disease worldwide. Although the
mortality rate of myocardial infarction (MI) has improved dramatically in recent years due to …

Role of NETosis in central nervous system injury

Y Chen, H Zhang, X Hu, W Cai, W Ni… - Oxidative medicine and …, 2022 - Wiley Online Library
Central nervous system (CNS) injury is divided into brain injury and spinal cord injury and
remains the most common cause of morbidity and mortality worldwide. Previous reviews …

NLRP3 inflammasome in cardiovascular diseases: pathophysiological and pharmacological implications

C Pellegrini, A Martelli, L Antonioli… - Medicinal Research …, 2021 - Wiley Online Library
Growing evidence points out the importance of nucleotide‐binding oligomerization domain
leucine‐rich repeat and pyrin domain‐containing protein 3 (NLRP3) inflammasome in the …

IL-1β in atherosclerotic vascular calcification: From bench to bedside

J Shen, M Zhao, C Zhang, X Sun - International Journal of …, 2021 - pmc.ncbi.nlm.nih.gov
Atherosclerotic vascular calcification contributes to increased risk of death in patients with
cardiovascular diseases. Assessing the type and severity of inflammation is crucial in the …

Circulating mitochondria promoted endothelial cGAS-derived neuroinflammation in subfornical organ to aggravate sympathetic overdrive in heart failure mice

S Zhang, D Zhao, Z Yang, F Wang, S Yang… - Journal of …, 2024 - Springer
Background Sympathoexcitation contributes to myocardial remodeling in heart failure (HF).
Increased circulating pro-inflammatory mediators directly act on the Subfornical organ …

Anthocyanin attenuates high salt-induced hypertension via inhibiting the hyperactivity of the sympathetic nervous system

C Xu, J Zhu, G Gong, L Guo, Y Zhang… - Clinical and …, 2023 - Taylor & Francis
Background Anthocyanin plays a protective role in cardiovascular disease through
antioxidant effect. Whether anthocyanin can reduce salt-induced hypertension and the …