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Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
P Sharma, P Srivastava, A Seth, PN Tripathi… - Progress in …, 2019 - Elsevier
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …
aging population worldwide. The enormous challenge which AD possesses to global …
Update on COX-2 selective inhibitors: Chemical classification, side effects and their use in cancers and neuronal diseases
AM Rayar, N Lagarde, C Ferroud… - Current topics in …, 2017 - ingentaconnect.com
Inflammation is a complex phenomenon necessary in human defense mechanisms but also
involved in the development of some human diseases. The discovery of cyclooxygenase-2 …
involved in the development of some human diseases. The discovery of cyclooxygenase-2 …
Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4 (3H)-quinazolinones
AM Alaa, LA Abou-Zeid, KEH ElTahir, RR Ayyad… - European Journal of …, 2016 - Elsevier
A new series of 2-substituted mercapto-4 (3H)-quinazolinone 1–26 were synthesized and
assessed for in vivo anti-inflammatory and analgesic activities and in vitro inhibition of …
assessed for in vivo anti-inflammatory and analgesic activities and in vitro inhibition of …
Synthesis and anti-inflammatory activity of sulfonamides and carboxylates incorporating trimellitimides: Dual cyclooxygenase/carbonic anhydrase inhibitory actions
AM Alaa, A Angeli, AS El-Azab, MEA Hammouda… - Bioorganic …, 2019 - Elsevier
Trimellitimides 6–21 were prepared and investigated in vivo for anti-inflammatory and
ulcerogenic effects and in vitro for cytotoxicity. They were subjected to in vitro …
ulcerogenic effects and in vitro for cytotoxicity. They were subjected to in vitro …
[HTML][HTML] Synthesis, molecular docking study, and biological evaluation and of new thiadiazole and thiazole derivatives incorporating isoindoline-1, 3-dione moiety as …
To highlight the importance of thiazole and thiadiazole derivatives in the progression of
cancer and microbial treatments and to aid in drug design, we have synthesized a new …
cancer and microbial treatments and to aid in drug design, we have synthesized a new …
Design, synthesis of 2, 3-disubstitued 4 (3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking …
AM Alaa, LA Abou-Zeid, KEH ElTahir… - Bioorganic & Medicinal …, 2016 - Elsevier
A new series, 2-substituted mercapto-3-[2-(pyridin-2-yl) ethyl]-4 (3H)-quinazolinone 1–21,
was synthesized and evaluated for in vivo anti-inflammatory and analgesic activities and in …
was synthesized and evaluated for in vivo anti-inflammatory and analgesic activities and in …
Synthesis, cytotoxic evaluation, and molecular docking studies of novel quinazoline derivatives with benzenesulfonamide and anilide tails: Dual inhibitors of EGFR …
HM Alkahtani, AN Abdalla, AJ Obaidullah… - Bioorganic …, 2020 - Elsevier
We synthesized a new series of 2-[(3-(4-sulfamoylphenethyl)-4 (3H)-quinazolinon-2-yl) thio]
anilide derivatives (2–16) and evaluated their cytotoxic activity against breast …
anilide derivatives (2–16) and evaluated their cytotoxic activity against breast …
Synthesis, molecular docking, analgesic, anti-inflammatory, and ulcerogenic evaluation of thiophene-pyrazole candidates as COX, 5-LOX, and TNF-α inhibitors
The thiophene bearing pyrazole derivatives (7a-j) were synthesized and examined for their
in vitro cyclooxygenase, 5-lipoxygenase, and tumour inducing factor-α inhibitory activities …
in vitro cyclooxygenase, 5-lipoxygenase, and tumour inducing factor-α inhibitory activities …
Synthesis, biological activity and molecular modeling study of novel 1,2,4-triazolo[4,3-b][1,2,4,5]tetrazines and 1,2,4-triazolo[4,3-b][1,2,4]triazines
AAM El-Reedy, NK Soliman - Scientific reports, 2020 - nature.com
Abstract Different novel 1, 2, 4-triazolo [4, 3-b][1, 2, 4, 5] tetrazines and 1, 2, 4-triazolo [4, 3-
b][1, 2, 4] triazines have been obtained from heterocyclization of 3-substituted-4-amino-5 …
b][1, 2, 4] triazines have been obtained from heterocyclization of 3-substituted-4-amino-5 …
Anti-inflammatory activity of novel thiosemicarbazone compounds indole-based as COX inhibitors
ÍTT Jacob, FOS Gomes, MDS de Miranda… - Pharmacological …, 2021 - Springer
Background In this article, a series of 20 new thiosemicarbazone derivatives containing
indole were synthesized and evaluated for their anti-inflammatory potential. Methods The …
indole were synthesized and evaluated for their anti-inflammatory potential. Methods The …