Site-selective modification strategies in antibody–drug conjugates

SJ Walsh, JD Bargh, FM Dannheim… - Chemical Society …, 2021 - pubs.rsc.org
Antibody–drug conjugates (ADCs) harness the highly specific targeting capabilities of an
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …

ImmunoPET: concept, design, and applications

W Wei, ZT Rosenkrans, J Liu, G Huang, QY Luo… - Chemical …, 2020 - ACS Publications
Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

The evolving landscape of antibody–drug conjugates: In depth analysis of recent research progress

JM Sasso, R Tenchov, R Bird, KA Iyer… - Bioconjugate …, 2023 - ACS Publications
Antibody–drug conjugates (ADCs) are targeted immunoconjugate constructs that integrate
the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …

Challenges in the use of sortase and other peptide ligases for site-specific protein modification

HE Morgan, WB Turnbull, ME Webb - Chemical Society Reviews, 2022 - pubs.rsc.org
Site-specific protein modification is a widely-used biochemical tool. However, there are
many challenges associated with the development of protein modification techniques, in …

Butterfly Pea (Clitoria ternatea), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine

GK Oguis, EK Gilding, MA Jackson… - Frontiers in plant …, 2019 - frontiersin.org
The perennial leguminous herb Clitoria ternatea (butterfly pea) has attracted significant
interest based on its agricultural and medical applications, which range from use as a fodder …

Nature-inspired protein ligation and its applications

R Pihl, Q Zheng, Y David - Nature Reviews Chemistry, 2023 - nature.com
The ability to manipulate the chemical composition of proteins and peptides has been
central to the development of improved polypeptide-based therapeutics and has enabled …

Contemporary Approaches for Site‐Selective Dual Functionalization of Proteins

L Xu, SL Kuan, T Weil - Angewandte Chemie International …, 2021 - Wiley Online Library
Site‐selective protein functionalization serves as an invaluable tool for investigating protein
structures and functions in complicated cellular environments and accomplishing semi …

Exploring cellular biochemistry with nanobodies

RW Cheloha, TJ Harmand, C Wijne… - Journal of Biological …, 2020 - ASBMB
Reagents that bind tightly and specifically to biomolecules of interest remain essential in the
exploration of biology and in their ultimate application to medicine. Besides ligands for …

Site-specific dual encoding and labeling of proteins via genetic code expansion

RM Bednar, PA Karplus, RA Mehl - Cell chemical biology, 2023 - cell.com
The ability to selectively modify proteins at two or more defined locations opens new
avenues for manipulating, engineering, and studying living systems. As a chemical biology …

Site-selective modification of peptide backbones

A Boto, CC González, D Hernández… - Organic Chemistry …, 2021 - pubs.rsc.org
The site-selective modification of peptide backbones allows an outstanding fine-tuning of
peptide conformation, folding ability, and physico-chemical and biological properties …