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Site-selective modification strategies in antibody–drug conjugates
Antibody–drug conjugates (ADCs) harness the highly specific targeting capabilities of an
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …
ImmunoPET: concept, design, and applications
W Wei, ZT Rosenkrans, J Liu, G Huang, QY Luo… - Chemical …, 2020 - ACS Publications
Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …
The evolving landscape of antibody–drug conjugates: In depth analysis of recent research progress
Antibody–drug conjugates (ADCs) are targeted immunoconjugate constructs that integrate
the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …
the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …
Challenges in the use of sortase and other peptide ligases for site-specific protein modification
Site-specific protein modification is a widely-used biochemical tool. However, there are
many challenges associated with the development of protein modification techniques, in …
many challenges associated with the development of protein modification techniques, in …
Butterfly Pea (Clitoria ternatea), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine
GK Oguis, EK Gilding, MA Jackson… - Frontiers in plant …, 2019 - frontiersin.org
The perennial leguminous herb Clitoria ternatea (butterfly pea) has attracted significant
interest based on its agricultural and medical applications, which range from use as a fodder …
interest based on its agricultural and medical applications, which range from use as a fodder …
Nature-inspired protein ligation and its applications
The ability to manipulate the chemical composition of proteins and peptides has been
central to the development of improved polypeptide-based therapeutics and has enabled …
central to the development of improved polypeptide-based therapeutics and has enabled …
Contemporary Approaches for Site‐Selective Dual Functionalization of Proteins
Site‐selective protein functionalization serves as an invaluable tool for investigating protein
structures and functions in complicated cellular environments and accomplishing semi …
structures and functions in complicated cellular environments and accomplishing semi …
Exploring cellular biochemistry with nanobodies
Reagents that bind tightly and specifically to biomolecules of interest remain essential in the
exploration of biology and in their ultimate application to medicine. Besides ligands for …
exploration of biology and in their ultimate application to medicine. Besides ligands for …
Site-specific dual encoding and labeling of proteins via genetic code expansion
The ability to selectively modify proteins at two or more defined locations opens new
avenues for manipulating, engineering, and studying living systems. As a chemical biology …
avenues for manipulating, engineering, and studying living systems. As a chemical biology …
Site-selective modification of peptide backbones
A Boto, CC González, D Hernández… - Organic Chemistry …, 2021 - pubs.rsc.org
The site-selective modification of peptide backbones allows an outstanding fine-tuning of
peptide conformation, folding ability, and physico-chemical and biological properties …
peptide conformation, folding ability, and physico-chemical and biological properties …