Untangling the genetics of beta cell dysfunction and death in type 1 diabetes

CC Robertson, RM Elgamal, BA Henry-Kanarek… - Molecular …, 2024 - Elsevier
Abstract Type 1 diabetes (T1D) is a complex multi-system disease which arises from both
environmental and genetic factors, resulting in the destruction of insulin-producing …

Diabetes and obesity: leveraging heterogeneity for precision medicine

PW Franks, JL Sargent - European Heart Journal, 2024 - academic.oup.com
The increasing prevalence of diabetes, obesity, and their cardiometabolic sequelae present
major global health challenges and highlight shortfalls of current approaches to the …

The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the …

SJ Hanna, RH Bonami, B Corrie, M Westley, AL Posgai… - Diabetologia, 2025 - Springer
Human molecular genetics has brought incredible insights into the variants that confer risk
for the development of tissue-specific autoimmune diseases, including type 1 diabetes. The …

[HTML][HTML] Estimation of individual positive anti-islet autoantibodies from 3 Screen ICA titer

E Kawasaki, H **nouchi, Y Maeda, A Okada… - International Journal of …, 2024 - mdpi.com
The 3 Screen ICA ELISA is a novel assay capable of simultaneously measuring
autoantibodies to glutamic acid decarboxylase (GADA), insulinoma-associated antigen-2 (IA …

[HTML][HTML] Evaluation of Biochemical Characteristics and Performance of the 3 Screen ICA ELISA Kit

E Kawasaki, Y Takahashi, T Komeda… - International Journal of …, 2024 - mdpi.com
We conducted a fundamental evaluation of the 3 Screen ICA ELISA kit, which can
simultaneously measure three major anti-islet autoantibodies important in diagnosing and …

Shifting the paradigm of type 1 diabetes: a narrative review of disease modifying therapies

AJ O'Donovan, S Gorelik, LM Nally - Frontiers in Endocrinology, 2024 - frontiersin.org
A new diagnosis of type 1 diabetes (T1D) may be accompanied by numerous lifelong
financial, emotional, and physical challenges, thus advancements in therapies that can …

[HTML][HTML] Changes in CD4+ CD25HIGH T cells and TGFβ1 levels in different stages of adult-onset type 1 diabetes

T Miličić, A Jotić, I Marković, D Popadić… - Journal of Medical …, 2024 - pmc.ncbi.nlm.nih.gov
Background Previous studies suggested an important role of impairments in T cell subsets in
different stages during type 1 diabetes (T1D) development, while data regarding CD25high …

Promene nivoa CD4+ CD25high T ćelija i TGFβ1 u različitim stadijumima adultnog Tipa 1 dijabetesa

T Miličić, A Jotic, I Markovic, D Popadic… - Journal of Medical …, 2024 - aseestant.ceon.rs
Background. Previous studies suggested important role of impairments in T cells subsets in
different stages during type 1 diabetes (T1D) development, while data regarding CD25 high …

Evolution of biosynthetic human insulin and its analogues for diabetes management.

D Francis, AM Chacko, A Anoop… - Advances in Protein …, 2024 - europepmc.org
Hormones play a crucial role in maintaining the normal human physiology. By acting as
chemical messengers that facilitate the communication between different organs, tissues …

[HTML][HTML] Основные эпидемиологические показатели сахарного диабета 1 типа у детей в Российской Федерации за 2014–2023 годы

ДН Лаптев, ОВ Безлепкина, ЕЛ Шешко… - Problems of …, 2024 - pmc.ncbi.nlm.nih.gov
ОБОСНОВАНИЕ ОБОСНОВАНИЕ. Сахарный диабет 1 типа (СД1) является наиболее
распространенной формой сахарного диабета в детском возрасте, где, в отличие от …