Clustered DNA double-strand breaks: biological effects and relevance to cancer radiotherapy
Cells manage to survive, thrive, and divide with high accuracy despite the constant threat of
DNA damage. Cells have evolved with several systems that efficiently repair spontaneous …
DNA damage. Cells have evolved with several systems that efficiently repair spontaneous …
Roadmap for metal nanoparticles in radiation therapy: Current status, translational challenges, and future directions
This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of
radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z= 22, to …
radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z= 22, to …
Recent improvements of the particle and heavy ion transport code system–PHITS version 3.33
ABSTRACT The Particle and Heavy Ion Transport code System (PHITS) is a general-
purpose Monte Carlo radiation transport code that can simulate the behavior of most particle …
purpose Monte Carlo radiation transport code that can simulate the behavior of most particle …
Ionizing radiation and complex DNA damage: from prediction to detection challenges and biological significance
Biological responses to ionizing radiation (IR) have been studied for many years, generally
showing the dependence of these responses on the quality of radiation, ie, the radiation …
showing the dependence of these responses on the quality of radiation, ie, the radiation …
TOPAS-nBio: an extension to the TOPAS simulation toolkit for cellular and sub-cellular radiobiology
The TOPAS Monte Carlo (MC) system is used in radiation therapy and medical imaging
research, having played a significant role in making Monte Carlo simulations widely …
research, having played a significant role in making Monte Carlo simulations widely …
Ionizing radiation and complex DNA damage: quantifying the radiobiological damage using Monte Carlo simulations
Ionizing radiation is a common tool in medical procedures. Monte Carlo (MC) techniques are
widely used when dosimetry is the matter of investigation. The scientific community has …
widely used when dosimetry is the matter of investigation. The scientific community has …
Mechanistic modelling of radiation responses
Radiobiological modelling has been a key part of radiation biology and therapy for many
decades, and many aspects of clinical practice are guided by tools such as the linear …
decades, and many aspects of clinical practice are guided by tools such as the linear …
Modelling variable proton relative biological effectiveness for treatment planning
A McNamara, H Willers… - The British journal of …, 2020 - academic.oup.com
Dose in proton radiotherapy is generally prescribed by scaling the physical proton dose by a
constant value of 1.1. Relative biological effectiveness (RBE) is defined as the ratio of doses …
constant value of 1.1. Relative biological effectiveness (RBE) is defined as the ratio of doses …
Ionization detail parameters and cluster dose: a mathematical model for selection of nanodosimetric quantities for use in treatment planning in charged particle …
B Faddegon, EA Blakely, L Burigo… - Physics in Medicine …, 2023 - iopscience.iop.org
Objective. To propose a mathematical model for applying ionization detail (ID), the detailed
spatial distribution of ionization along a particle track, to proton and ion beam radiotherapy …
spatial distribution of ionization along a particle track, to proton and ion beam radiotherapy …
Simulation of DNA damage using Geant4‐DNA: an overview of the “molecularDNA” example application
Purpose The scientific community shows great interest in the study of DNA damage
induction, DNA damage repair, and the biological effects on cells and cellular systems after …
induction, DNA damage repair, and the biological effects on cells and cellular systems after …