Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

The cytoskeleton and its components—actin, microtubules and intermediate filaments—
have been studied for decades, and multiple roles of the individual cytoskeletal …

During epithelial tissue development, repair, and homeostasis, adherens junctions (AJs)
ensure intercellular adhesion and tissue integrity while allowing for cell and tissue …

Mitotic spindle orientation is essential for cell fate decisions, epithelial maintenance, and
tissue morphogenesis. In most animal cell types, the dynein motor complex is anchored at …

In multicellular systems, oriented cell divisions are essential for morphogenesis and
homeostasis as they determine the position of daughter cells within the tissue and also, in …

There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …

All cells sense and respond to various mechanical forces in and mechanical properties of
their environment. To respond appropriately, cells must be able to sense the location …

Morphogenesis is the remarkable process by which cells self-assemble into complex tissues
and organs that exhibit specialized form and function during embryological development …

The seminal observation that mechanical signals can elicit changes in biochemical
signalling within cells, a process commonly termed mechanosensation and …

The centrosome acts as the main microtubule-nucleating organelle in animal cells and plays
a critical role in mitotic spindle orientation and in genome stability. Yet, despite its central …