Optical genome map** (OGM) is a new genome-wide technology that can reveal both
structural genomic variations (SVs) and copy number variations (CNVs) in a single assay …

Despite its relatively recent emergence, single-cell sequencing has cemented its place in
scientific research. It has grown exponentially in less than two decades since its start, with …

Activating point mutations of the RAS gene act as driver mutations for a subset of precursor‐
B cell acute lymphoblastic leukaemias (pre‐B ALL) and represent an ambitious target for …

Despite recent progress in identifying the genetic drivers of acute lymphoblastic leukemia
(ALL), prognosis remains poor for those individuals who experience disease recurrence …

Leukemia is a malignant tumor with high heterogeneity and a complex evolutionary process.
It is difficult to resolve the heterogeneity and clonal evolution of leukemia cells by applying …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer with resistant clonal
propagation in recurrence. We performed high-throughput droplet-based 5′ single-cell …

B‐acute lymphoblastic leukaemia (B‐ALL) is a haematological disease resulting from
haematopoietic system dysfunction, leading to the unchecked growth of immature B …

Acute lymphoblastic leukemia (ALL) is the most common cancer in children. ALL originates
from precursor lymphocytes that acquire multiple genomic changes over time, including …

Drug resistance and treatment failure in pediatric acute lymphoblastic leukemia (ALL) are in
part driven by tumor heterogeneity and clonal evolution. Although bulk tumor genomic …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive type of leukemia caused by
accumulation of multiple genetic alterations in T-cell progenitors. However, for many genes it …