The human connectome in Alzheimer disease—relationship to biomarkers and genetics

M Yu, O Sporns, AJ Saykin - Nature Reviews Neurology, 2021 - nature.com
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease

X Wang, W Huang, L Su, Y **ng, F Jessen… - Molecular …, 2020 - Springer
Subjective cognitive decline (SCD) is regarded as the first clinical manifestation in the
Alzheimer's disease (AD) continuum. Investigating populations with SCD is important for …

[HTML][HTML] A review of the application of deep learning in the detection of Alzheimer's disease

S Gao, D Lima - International Journal of Cognitive Computing in …, 2022 - Elsevier
Alzheimer's disease (AD) is the most common chronic disease in the elderly, with a high
incidence rate. In recent years, deep learning has become popular in the field of medical …

[HTML][HTML] Fractal dimension of the brain in neurodegenerative disease and dementia: A systematic review

ET Ziukelis, E Mak, ME Dounavi, L Su… - Ageing research reviews, 2022 - Elsevier
Sensitive and specific antemortem biomarkers of neurodegenerative disease and dementia
are crucial to the pursuit of effective treatments, required both to reliably identify disease and …

Minor neuropsychological deficits in patients with subjective cognitive decline

S Wolfsgruber, L Kleineidam, J Guski, A Polcher… - Neurology, 2020 - AAN Enterprises
Objective To determine the nature and extent of minor neuropsychological deficits in
patients with subjective cognitive decline (SCD) and their association with CSF biomarkers …

[HTML][HTML] Open science datasets from PREVENT-AD, a longitudinal cohort of pre-symptomatic Alzheimer's disease

J Tremblay-Mercier, C Madjar, S Das, AP Binette… - NeuroImage: Clinical, 2021 - Elsevier
Abstract To move Alzheimer Disease (AD) research forward it is essential to collect data
from large cohorts, but also make such data available to the global research community. We …

[HTML][HTML] Distinct disruptive patterns of default mode subnetwork connectivity across the spectrum of preclinical Alzheimer's disease

C Xue, B Yuan, Y Yue, J Xu, S Wang, M Wu… - Frontiers in Aging …, 2019 - frontiersin.org
Background: The early progression continuum of Alzheimer's disease (AD) has been
considered to advance through subjective cognitive decline (SCD), non-amnestic mild …

Detecting early cognitive decline in alzheimer's disease with brain synaptic structural and functional evaluation

S Ribarič - Biomedicines, 2023 - mdpi.com
Early cognitive decline in patients with Alzheimer's (AD) is associated with quantifiable
structural and functional connectivity changes in the brain. AD dysregulation of Aβ and tau …

Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease

E Ersoezlue, BS Rauchmann, T Schneider-Axmann… - Neurobiology of …, 2023 - Elsevier
Alzheimer's disease (AD) is associated with alterations in functional connectivity (FC) of the
brain. The FC underpinnings of CR, that is, lifelong experiences, are largely unknown …

Cerebral hyperactivation across the Alzheimer's disease pathological cascade

N Corriveau-Lecavalier, JN Adams… - Brain …, 2024 - academic.oup.com
Neuronal dysfunction in specific brain regions or across distributed brain networks is a
known feature of Alzheimer's disease. An often reported finding in the early stage of the …