Role of the immune system in hypertension
High blood pressure is present in more than one billion adults worldwide and is the most
important modifiable risk factor of death resulting from cardiovascular disease. While many …
important modifiable risk factor of death resulting from cardiovascular disease. While many …
Renal metabolism and hypertension
Z Tian, M Liang - Nature communications, 2021 - nature.com
Hypertension is a leading risk factor for disease burden worldwide. The kidneys, which have
a high specific metabolic rate, play an essential role in the long-term regulation of arterial …
a high specific metabolic rate, play an essential role in the long-term regulation of arterial …
Emerging role of the inflammasome and pyroptosis in hypertension
Inflammasomes are components of the innate immune response that have recently emerged
as crucial controllers of tissue homeostasis. In particular, the nucleotide-binding domain …
as crucial controllers of tissue homeostasis. In particular, the nucleotide-binding domain …
Immune mechanisms of salt-sensitive hypertension and renal end-organ damage
DL Mattson - Nature Reviews Nephrology, 2019 - nature.com
Immune mechanisms have been recognized to have a role in the pathogenesis of
hypertension, vascular disease and kidney damage in humans and animals for many …
hypertension, vascular disease and kidney damage in humans and animals for many …
Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasome
Salt-sensitivity of blood pressure is an independent risk factor for cardiovascular disease
and affects approximately half of the hypertensive population. While the precise …
and affects approximately half of the hypertensive population. While the precise …
Immune mechanisms in hypertension and vascular injury
EL Schiffrin - Clinical science, 2014 - portlandpress.com
Over the last 20 years it has become recognized that low-grade inflammation plays a role in
cardiovascular disease. More recently, participation of the innate and the adaptive immune …
cardiovascular disease. More recently, participation of the innate and the adaptive immune …
Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage
DL Mattson, H Lund, C Guo… - American Journal …, 2013 - journals.physiology.org
Hypertension and renal damage in Dahl SS rats are associated with increased infiltrating
immune cells in the kidney. To examine the role of infiltrating immune cells in this disease …
immune cells in the kidney. To examine the role of infiltrating immune cells in this disease …
Adaptive immunity in hypertension
TP Mikolajczyk, TJ Guzik - Current hypertension reports, 2019 - Springer
Abstract Purpose of Review In recent years, a vast body of evidence has accumulated
indicating the role of the immune system in the regulation of blood pressure and modulation …
indicating the role of the immune system in the regulation of blood pressure and modulation …
Infiltrating immune cells in the kidney in salt-sensitive hypertension and renal injury
DL Mattson - American Journal of Physiology-Renal …, 2014 - journals.physiology.org
The importance of the immune system in hypertension, vascular disease, and renal disease
has been appreciated for over 50 years. Recent experimental advances have led to a …
has been appreciated for over 50 years. Recent experimental advances have led to a …
Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans
Compelling evidence for the inherited nature of essential hypertension has led to extensive
research in rats and humans. Rats have served as the primary model for research on the …
research in rats and humans. Rats have served as the primary model for research on the …