Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers.
Their ubiquitously expressed protein products are implicated in processes fundamental to all …

Genomes are transmitted faithfully from dividing cells to their offspring. Changes that occur
during DNA repair, chromosome duplication, and transmission or via recombination provide …

Abstract The Saccharomyces cerevisiae Pif1 helicase is the prototypical member of the Pif1
DNA helicase family, which is conserved from bacteria to humans. Here we show that …

Genome instability, a hallmark of cancer progression, is thought to arise through DNA
double strand breaks (DSBs). Studies in yeast and mammalian cells have shown that DSBs …

Genomic instability in the form of mutations and chromosome rearrangements is usually
associated with pathological disorders, and yet it is also crucial for evolution. Two types of …

Mutations are typically perceived as random, independent events. We describe here
nonrandom clustered mutations in yeast and in human cancers. Genome sequencing of …

Replication protein A (RPA) is an essential eukaryotic single-stranded DNA binding protein
with a central role in DNA metabolism. RPA directly participates in DNA double-strand break …

The process of homologous recombination is a major DNA repair pathway that operates on
DNA double-strand breaks, and possibly other kinds of DNA lesions, to promote error-free …

The pathways involved in suppressing DNA replication stress and the associated DNA
damage are critical to maintaining genome integrity. The Mre11 complex is unique among …

Individuals carrying BRCA2 mutations are predisposed to breast and ovarian cancers. Here,
we show that BRCA2 plays a dual role in regulating the actions of RAD51, a protein …