CMV is an ancient herpesvirus that has co-evolved with its host over millions of years. The
236 kbp genome encodes at least 165 genes, four non-coding RNAs and 14 miRNAs. Of the …

While the host immune response following primary human cytomegalovirus (HCMV)
infection is generally effective at stop** virus replication and dissemination, virus is never …

Abstract miRNAs are single‐stranded ncRNAs that act as regulators of different human body
processes. Several miRNAs have been noted to control the human immune and …

The human cytomegalovirus (HCMV), whose genome is 235±1.9 kbp long, is a common
herpesvirus. However, the functions of many of its genes are still unknown. HCMV is closely …

The successful establishment and maintenance of human cytomegalovirus (HCMV) latency
is dependent on the expression of a subset of viral genes. Whilst the exact spectrum and …

Background MicroRNAs (miRNAs) are small non-coding RNAs about 22 nucleotides in
length, which play an important role in gene regulation of both eukaryotes and viruses. They …

Interpretation of clinical data regarding the impact of cytomegalovirus (CMV) infection on
allograft function is complicated by the diversity of viral strains and substantial variability of …

Intrinsic immune defenses mediated by restriction factors inhibit productive viral infections.
Select viruses rapidly establish latent infections and, with gene expression profiles that imply …

The identification of virally encoded microRNAs (miRNAs) has had a major impact on the
field of herpes virology. Given their ability to target cellular and viral transcripts, and the lack …

Glioblastoma multiforme (GBM) is the most aggressive neoplastic brain tumor in humans
with a median survival of less than 2 years. It is therefore critical to understand the …