Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications

Y Li, Y Liu, XY Yu, Y Xu, X Pan, Y Sun… - … and Targeted Therapy, 2024 - nature.com
Once considered unconventional cellular structures, membraneless organelles (MLOs),
cellular substructures involved in biological processes or pathways under physiological …

Plants use molecular mechanisms mediated by biomolecular condensates to integrate environmental cues with development

S Field, GJ Jang, C Dean, LC Strader, SY Rhee - The Plant Cell, 2023 - academic.oup.com
This review highlights recent literature on biomolecular condensates in plant development
and discusses challenges for fully dissecting their functional roles. Plant developmental …

Multi-omics landscape and molecular basis of radiation tolerance in a tardigrade

L Li, Z Ge, S Liu, K Zheng, Y Li, K Chen, Y Fu, X Lei… - Science, 2024 - science.org
Tardigrades are captivating organisms known for their resilience in extreme environments,
including ultra-high-dose radiation, but the underlying mechanisms of this resilience remain …

Liquid–liquid phase separation in plants: Advances and perspectives from model species to crops

Q Liu, W Liu, Y Niu, T Wang, J Dong - Plant Communications, 2024 - cell.com
Membraneless biomolecular condensates play important roles in both normal biological
activities and responses to environmental stimuli in living organisms. Liquid‒liquid phase …

Cold induction of nuclear FRIGIDA condensation in Arabidopsis

Z Zhang, X Luo, Y Yang, Y He - Nature, 2023 - nature.com
Cold induction of nuclear FRIGIDA condensation in Arabidopsis | Nature Skip to main content
Thank you for visiting nature.com. You are using a browser version with limited support for …

Recent advances in engineering synthetic biomolecular condensates

L Wan, J Ke, Y Zhu, W Zhang, W Mu - Biotechnology Advances, 2024 - Elsevier
Biomolecular condensates are intriguing entities found within living cells. These structures
possess the ability to selectively concentrate specific components through phase separation …

β-synuclein regulates the phase transitions and amyloid conversion of α-synuclein

X Li, L Yu, X Liu, T Shi, Y Zhang, Y **ao… - Nature …, 2024 - nature.com
Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB) are neurodegenerative
disorders characterized by the accumulation of α-synuclein aggregates. α-synuclein forms …

Coacervate vesicles assembled by liquid–liquid phase separation improve delivery of biopharmaceuticals

P Wen, H Huang, R Zhang, H Zheng, T Liang… - Nature Chemistry, 2025 - nature.com
Vesicles play critical roles in cellular materials storage and signal transportation, even in the
formation of organelles and cells. Natural vesicles are composed of a lipid layer that forms a …

MolPhase, an advanced prediction algorithm for protein phase separation

Q Liang, N Peng, Y **e, N Kumar, W Gao… - The EMBO …, 2024 - embopress.org
We introduce MolPhase, an advanced algorithm for predicting protein phase separation
(PS) behavior that improves accuracy and reliability by utilizing diverse physicochemical …

METTL3/METTL14 maintain human nucleoli integrity by mediating SUV39H1/H2 degradation

Y Shan, Y Zhang, Y Wei, C Zhang, H Lin, J He… - Nature …, 2024 - nature.com
Nucleoli are fundamentally essential sites for ribosome biogenesis in cells and formed by
liquid-liquid phase separation (LLPS) for a multilayer condensate structure. How the nucleoli …