Endosomes, lysosomes and lysosome-related organelles are emerging as important Ca2+
storage cellular compartments with a central role in intracellular Ca2+ signalling …

Since the discovery of the Ca 2+ mobilizing effects of the pyridine nucleotide metabolite,
nicotinic acid adenine dinucleotide phosphate (NAADP), this molecule has been …

Lysosomes have traditionally been viewed as degradative organelles, although a growing
body of evidence suggests that they can function as Ca 2+ stores. Here we examined the …

The endoplasmic reticulum (ER) and acidic organelles (endo-lysosomes) act as separate
Ca2+ stores that release Ca2+ in response to the second messengers IP3 and cADPR (ER) …

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a ubiquitous messenger
proposed to stimulate Ca 2+ release from acidic organelles via two-pore channels (TPCs). It …

Upon stimulation of membrane receptors, nicotinic acid adenine dinucleotide phosphate
(NAADP) is formed as second messenger within seconds and evokes Ca2+ signaling in …

Recently, we identified, for the first time, two-pore channels (TPCs, TPCN for gene name) as
a novel family of nicotinic acid adenine dinucleotide phosphate (NAADP)-gated …

Cytosolic Ca2+ signals are organized in complex spatial and temporal patterns that underlie
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …

Acidic Ca 2+ stores refer to a collection of H+-and Ca 2+-rich organelles involved in Ca 2+
signalling across taxonomic kingdoms. They include lysosomes, lysosome-related …

Recent studies have demonstrated that the majority of endogenous cannabinoid type 1 (CB
1) receptors do not reach the cell surface but are instead associated with endosomal and …