Even though the functional role of mRNA molecules is primarily decided by the nucleotide
sequence, several properties are determined by secondary structure conformations …

Cytokines are critical mediators of inflammation and host immune defense. Cytokine
production is regulated at both transcriptional and post-transcriptional levels. Post …

The RNA-binding proteins Roquin-1/2 and Regnase-1 exert essential regulation by
controlling pro-inflammatory mRNA expression to prevent autoimmune disease. More …

Adenylate/uridylate-rich elements (AREs) are the most common cis-regulatory elements in
the 3′-untranslated region (UTR) of mRNAs, where they fine-tune turnover by mediating …

ABSTRACT RNA cis elements play pivotal roles in regulatory processes, eg in
transcriptional and translational regulation. Two stem-looped cis elements, the constitutive …

Highlights•Roquin and Regnase-1 regulate shared mRNA targets via stem-loops in their 3′
UTRs.•Roquin and Regnase-1 are inactivated by MALT1 cleavage upon T cell stimulation.• …

Post-transcriptional gene regulation controls the amount of protein produced from a specific
mRNA by altering both its decay and translation rates. Such regulation is primarily achieved …

Posttranscriptional regulation of gene expression plays a central role in the initiation of
innate and adaptive immune responses. This is exemplified by the protein Roquin, which …

Chemical probing experiments such as SHAPE are routinely used to probe RNA molecules.
In this work, we use atomistic molecular dynamics simulations to test the hypothesis that …

Excess or sustained production of cytokines in innate immune cells leads to the
development of chronic inflammatory diseases, such as autoimmune diseases. In …