Regulation of bacterial virulence by Csr (Rsm) systems

CA Vakulskas, AH Potts, P Babitzke… - Microbiology and …, 2015 - journals.asm.org
Most bacterial pathogens have the remarkable ability to flourish in the external environment
and in specialized host niches. This ability requires their metabolism, physiology, and …

Gac/Rsm signal transduction pathway of γ‐proteobacteria: from RNA recognition to regulation of social behaviour

K Lapouge, M Schubert, FHT Allain… - Molecular …, 2008 - Wiley Online Library
In many γ‐proteobacteria, the conserved GacS/GacA (BarA/UvrY) two‐component system
positively controls the expression of one to five genes specifying small RNAs (sRNAs) that …

Global regulation by CsrA and its RNA antagonists

T Romeo, P Babitzke - Microbiology spectrum, 2018 - journals.asm.org
The sequence-specific RNA binding protein CsrA is employed by diverse bacteria in the
posttranscriptional regulation of gene expression. Its binding interactions with RNA have …

Determination of the regulon and identification of novel mRNA targets of Pseudomonas aeruginosa RsmA

A Brencic, S Lory - Molecular microbiology, 2009 - Wiley Online Library
One of the prokaryotic post‐transcriptional regulatory mechanisms involves the CsrA/RsmA
family of proteins that act by modulating translation initiation at target mRNAs. In this study …

CsrB sRNA family: sequestration of RNA-binding regulatory proteins

P Babitzke, T Romeo - Current opinion in microbiology, 2007 - Elsevier
Noncoding regulatory RNA molecules, also known as small RNAs, participate in several
bacterial regulatory networks. The central component of the carbon storage regulator (Csr) …

Pseudomonas aeruginosa biofilm matrix polysaccharide Psl is regulated transcriptionally by RpoS and post‐transcriptionally by RsmA

Y Irie, M Starkey, AN Edwards, DJ Wozniak… - Molecular …, 2010 - Wiley Online Library
Extracellular polysaccharides are important components of biofilms. In non‐mucoid
Pseudomonas aeruginosa strains, the Pel and Psl polysaccharides are major structural …

Differentiate to thrive: lessons from the Legionella pneumophila life cycle

AB Molofsky, MS Swanson - Molecular microbiology, 2004 - Wiley Online Library
When confronted by disparate environments, microbes routinely alter their physiology to
tolerate or exploit local conditions. But some circumstances require more drastic remodelling …

Post‐transcriptional regulation on a global scale: form and function of Csr/Rsm systems

T Romeo, CA Vakulskas… - Environmental …, 2013 - Wiley Online Library
Originally described as a repressor of gene expression in the stationary phase of growth,
CsrA (RsmA) regulates primary and secondary metabolic pathways, biofilm formation …

RNA-binding proteins involved in post-transcriptional regulation in bacteria

E Van Assche, S Van Puyvelde… - Frontiers in …, 2015 - frontiersin.org
Post-transcriptional regulation is a very important mechanism to control gene expression in
changing environments. In the past decade, a lot of interest has been directed toward the …

CsrA post‐transcriptionally represses pgaABCD, responsible for synthesis of a biofilm polysaccharide adhesin of Escherichia coli

X Wang, AK Dubey, K Suzuki, CS Baker… - Molecular …, 2005 - Wiley Online Library
The RNA‐binding protein CsrA represses biofilm formation, while the non‐coding RNAs
CsrB and CsrC activate this process by sequestering CsrA. We now provide evidence that …