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Regulation of bacterial virulence by Csr (Rsm) systems
Most bacterial pathogens have the remarkable ability to flourish in the external environment
and in specialized host niches. This ability requires their metabolism, physiology, and …
and in specialized host niches. This ability requires their metabolism, physiology, and …
Gac/Rsm signal transduction pathway of γ‐proteobacteria: from RNA recognition to regulation of social behaviour
In many γ‐proteobacteria, the conserved GacS/GacA (BarA/UvrY) two‐component system
positively controls the expression of one to five genes specifying small RNAs (sRNAs) that …
positively controls the expression of one to five genes specifying small RNAs (sRNAs) that …
Global regulation by CsrA and its RNA antagonists
The sequence-specific RNA binding protein CsrA is employed by diverse bacteria in the
posttranscriptional regulation of gene expression. Its binding interactions with RNA have …
posttranscriptional regulation of gene expression. Its binding interactions with RNA have …
Determination of the regulon and identification of novel mRNA targets of Pseudomonas aeruginosa RsmA
A Brencic, S Lory - Molecular microbiology, 2009 - Wiley Online Library
One of the prokaryotic post‐transcriptional regulatory mechanisms involves the CsrA/RsmA
family of proteins that act by modulating translation initiation at target mRNAs. In this study …
family of proteins that act by modulating translation initiation at target mRNAs. In this study …
CsrB sRNA family: sequestration of RNA-binding regulatory proteins
Noncoding regulatory RNA molecules, also known as small RNAs, participate in several
bacterial regulatory networks. The central component of the carbon storage regulator (Csr) …
bacterial regulatory networks. The central component of the carbon storage regulator (Csr) …
Pseudomonas aeruginosa biofilm matrix polysaccharide Psl is regulated transcriptionally by RpoS and post‐transcriptionally by RsmA
Extracellular polysaccharides are important components of biofilms. In non‐mucoid
Pseudomonas aeruginosa strains, the Pel and Psl polysaccharides are major structural …
Pseudomonas aeruginosa strains, the Pel and Psl polysaccharides are major structural …
Differentiate to thrive: lessons from the Legionella pneumophila life cycle
AB Molofsky, MS Swanson - Molecular microbiology, 2004 - Wiley Online Library
When confronted by disparate environments, microbes routinely alter their physiology to
tolerate or exploit local conditions. But some circumstances require more drastic remodelling …
tolerate or exploit local conditions. But some circumstances require more drastic remodelling …
Post‐transcriptional regulation on a global scale: form and function of Csr/Rsm systems
Originally described as a repressor of gene expression in the stationary phase of growth,
CsrA (RsmA) regulates primary and secondary metabolic pathways, biofilm formation …
CsrA (RsmA) regulates primary and secondary metabolic pathways, biofilm formation …
RNA-binding proteins involved in post-transcriptional regulation in bacteria
E Van Assche, S Van Puyvelde… - Frontiers in …, 2015 - frontiersin.org
Post-transcriptional regulation is a very important mechanism to control gene expression in
changing environments. In the past decade, a lot of interest has been directed toward the …
changing environments. In the past decade, a lot of interest has been directed toward the …
CsrA post‐transcriptionally represses pgaABCD, responsible for synthesis of a biofilm polysaccharide adhesin of Escherichia coli
X Wang, AK Dubey, K Suzuki, CS Baker… - Molecular …, 2005 - Wiley Online Library
The RNA‐binding protein CsrA represses biofilm formation, while the non‐coding RNAs
CsrB and CsrC activate this process by sequestering CsrA. We now provide evidence that …
CsrB and CsrC activate this process by sequestering CsrA. We now provide evidence that …