The perinatal period has often been described as immune deficient. However, it has become
clear that immune responses in the neonate following exposure to microbes or as a result of …

Many mammalian species naturally undergo hibernation, a process that is associated with
drastic changes in metabolism and systemic physiology. Their ability to retain an …

Hypoxic-ischemic (HI) encephalopathy is a leading cause of dire mortality and morbidity in
neonates. Unfortunately, no effective therapies have been developed as of yet. Oxidative …

Neonatal hypoxia-ischemia encephalopathy (HIE) refers to a brain injury in term infants that
can lead to death or lifelong neurological deficits such as cerebral palsy (CP). The …

Neonatal hypoxic-ischemic encephalopathy (HIE) is an injury that often leads to detrimental
neurological deficits. Currently, there are no established therapies for HIE and it is critical to …

Background Brain injuries induced by hypoxia-ischemia in neonates contribute to increased
mortality and lifelong neurological dysfunction. The specific PKR inhibitor C16 has been …

Therapeutic hypothermia provides incomplete neuroprotection after hypoxia-ischemia (HI)-
induced brain injury in neonates. We previously showed that cortical neuron and white …

Sepsis-related laminitis (SRL) is a common complication in the septic/endotoxemic critically-
ill equine patient, in which lamellar injury and failure commonly lead to crippling distal …

Perinatal hypoxic-ischemic encephalopathy (HIE) can lead to neurodevelopmental
disorders, including cerebral palsy. Standard care for neonatal HIE includes therapeutic …

Alzheimer's disease (AD) is a neurodegenerative condition associated with loss of memory
function, depression and anxiety. The etiology of AD is poorly understood, but both …