Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …

The success of next-generation androgen receptor (AR) pathway inhibitors, such as
abiraterone acetate and enzalutamide, in treating prostate cancer has been hampered by …

The fact that the identity of the cells that initiate metastasis in most human cancers is
unknown hampers the development of antimetastatic therapies. Here we describe a …

Chemotherapy resistance observed in patients with colorectal cancer (CRC) may be related
to the presence of cancer stem cells (CSCs), but the underlying mechanism (s) remain …

Cancer Stem Cells (CSCs) are a sub-population of cells, identified in most tumors,
responsible for the initiation, recurrence, metastatic potential, and resistance of different …

A tumor originates from a normal cell that has undergone tumorigenic transformation as a
result of genetic mutations. This transformed cell is the cell-of-origin for the tumor. In contrast …

Cancer stem cells (CSCs) are inherently resistant to chemotherapy, and CSCs in
chemotherapy-failed recurrent tumors are enriched; however, the cellular origin of …

MicroRNAs play important roles in regulating tumour development, progression and
metastasis. Here we show that one of the miR-200 family members, miR-141, is under …

Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

Benign prostatic hyperplasia (BPH) is an enlargement of the prostate gland that is frequently
found in aging men. Androgens are essential for the development and differentiated function …