Endometriosis: Etiology, pathobiology, and therapeutic prospects
Endometriosis is a common condition associated with infertility that causes chronic pain in
many, but not all, women. It is defined by the presence of endometrial-like tissue outside the …
many, but not all, women. It is defined by the presence of endometrial-like tissue outside the …
Environmental factors in declining human fertility
A severe decline in child births has occurred over the past half century, which will lead to
considerable population declines, particularly in industrialized regions. A crucial question is …
considerable population declines, particularly in industrialized regions. A crucial question is …
The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions
Endometriosis is a common condition associated with debilitating pelvic pain and infertility.
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …
Gut microbiome heritability is nearly universal but environmentally contingent
Relatives have more similar gut microbiomes than nonrelatives, but the degree to which this
similarity results from shared genotypes versus shared environments has been …
similarity results from shared genotypes versus shared environments has been …
The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019
A Buniello, JAL MacArthur, M Cerezo… - Nucleic acids …, 2019 - academic.oup.com
The GWAS Catalog delivers a high-quality curated collection of all published genome-wide
association studies enabling investigations to identify causal variants, understand disease …
association studies enabling investigations to identify causal variants, understand disease …
Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
Cancer‐associated fibroblast‐mediated cellular crosstalk supports hepatocellular carcinoma progression
M Song, J He, QZ Pan, J Yang, J Zhao, YJ Zhang… - …, 2021 - Wiley Online Library
Background and Aims Cancer‐associated fibroblasts (CAFs) are key players in multicellular,
stromal‐dependent alterations leading to HCC pathogenesis. However, the intricate …
stromal‐dependent alterations leading to HCC pathogenesis. However, the intricate …
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits
Genetic correlations estimated from genome-wide association studies (GWASs) reveal
pervasive pleiotropy across a wide variety of phenotypes. We introduce genomic structural …
pervasive pleiotropy across a wide variety of phenotypes. We introduce genomic structural …
The nature of nurture: Effects of parental genotypes
Sequence variants in the parental genomes that are not transmitted to a child (the proband)
are often ignored in genetic studies. Here we show that nontransmitted alleles can affect a …
are often ignored in genetic studies. Here we show that nontransmitted alleles can affect a …