Thiazoles, their benzofused systems, and thiazolidinone derivatives: versatile and promising tools to combat antibiotic resistance
S Cascioferro, B Parrino, D Carbone… - Journal of medicinal …, 2020 - ACS Publications
Thiazoles, their benzofused systems, and thiazolidinone derivatives are widely recognized
as nuclei of great value for obtaining molecules with various biological activities, including …
as nuclei of great value for obtaining molecules with various biological activities, including …
A conceptual review of rhodanine: current applications of antiviral drugs, anticancer and antimicrobial activities
Rhodanines are accepted as advantaged heterocycles in medicinal chemistry as one of the
4-thiazolidinones subtypes. The aim of this paper is to analyze the features of rhodanine and …
4-thiazolidinones subtypes. The aim of this paper is to analyze the features of rhodanine and …
[HTML][HTML] Multitarget Pharmacology of Sulfur–Nitrogen Heterocycles: Anticancer and Antioxidant Perspectives
A Drakontaeidi, I Papanotas, E Pontiki - Antioxidants, 2024 - mdpi.com
Cancer and oxidative stress are interrelated, with reactive oxygen species (ROS) playing
crucial roles in physiological processes and oncogenesis. Excessive ROS levels can induce …
crucial roles in physiological processes and oncogenesis. Excessive ROS levels can induce …
Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive …
Quorum sensing (QS) inhibition is one of the potential methods to target bacterial infection.
In this study, comprehensive molecular dynamics simulation (MDS) experiments were …
In this study, comprehensive molecular dynamics simulation (MDS) experiments were …
Sonochemical synthesis of New Thiazolidin-4-one derivatives as potent anticancer and antimicrobial agents with Docking design, and Energy gap estimation
Thiazolidin-4-ones have important biological features, which has led to the development of
new derivatives employing an efficient ultrasonic method. Schiff base derivatives were …
new derivatives employing an efficient ultrasonic method. Schiff base derivatives were …
Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance
Antibiotic resistance is one of the most important challenges of the 21st century. However,
the growing understanding of bacterial pathogenesis and cell-to-cell communication has …
the growing understanding of bacterial pathogenesis and cell-to-cell communication has …
New benzothiazole-based thiazolidinones as potent antimicrobial agents. Design, synthesis and biological evaluation
Background: Thiazole and benzothiazole derivatives, as well as thiazolidinones are very
important scaffolds in medicinal chemistry. Literature has revealed that they possess a wide …
important scaffolds in medicinal chemistry. Literature has revealed that they possess a wide …
Identification of novel 4-thiazolidinones as new TcaR inhibitors: Design, synthesis, molecular docking, MD simulation, ADMET and in vitro antibacterial evaluation
Novel morpholine and piperazine-containing 4-thiazolidinone derivatives (6a-6e) and (7a-
7e) were designed and synthesized utilizing a multi-component reaction (MCR) to develop …
7e) were designed and synthesized utilizing a multi-component reaction (MCR) to develop …
Novel N-methylsulfonyl-indole derivatives: biological activity and COX-2/5-LOX inhibitory effect with improved gastro protective profile and reduced cardio vascular …
Three novel series of N-methylsulfonylindole derivatives 3a&b, 4a–e, and 5a–e were
synthesised. Different biological activities of the synthesised compounds were studied …
synthesised. Different biological activities of the synthesised compounds were studied …
New Substituted 5-Benzylideno-2-Adamantylthiazol[3,2-b][1,2,4]Triazol-6(5H)ones as Possible Anti-Inflammatory Agents
Background: Inflammation is a complex response to noxious stimuli promoted by the release
of chemical mediators from the damaged cells. Metabolic products of arachidonic acid …
of chemical mediators from the damaged cells. Metabolic products of arachidonic acid …