Thiazoles, their benzofused systems, and thiazolidinone derivatives: versatile and promising tools to combat antibiotic resistance

S Cascioferro, B Parrino, D Carbone… - Journal of medicinal …, 2020 - ACS Publications
Thiazoles, their benzofused systems, and thiazolidinone derivatives are widely recognized
as nuclei of great value for obtaining molecules with various biological activities, including …

A conceptual review of rhodanine: current applications of antiviral drugs, anticancer and antimicrobial activities

SM Mousavi, M Zarei, SA Hashemi… - Artificial cells …, 2019 - Taylor & Francis
Rhodanines are accepted as advantaged heterocycles in medicinal chemistry as one of the
4-thiazolidinones subtypes. The aim of this paper is to analyze the features of rhodanine and …

[HTML][HTML] Multitarget Pharmacology of Sulfur–Nitrogen Heterocycles: Anticancer and Antioxidant Perspectives

A Drakontaeidi, I Papanotas, E Pontiki - Antioxidants, 2024 - mdpi.com
Cancer and oxidative stress are interrelated, with reactive oxygen species (ROS) playing
crucial roles in physiological processes and oncogenesis. Excessive ROS levels can induce …

Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive …

RH Abd El-Aleam, AM Sayed, MN Taha… - European Journal of …, 2022 - Elsevier
Quorum sensing (QS) inhibition is one of the potential methods to target bacterial infection.
In this study, comprehensive molecular dynamics simulation (MDS) experiments were …

Sonochemical synthesis of New Thiazolidin-4-one derivatives as potent anticancer and antimicrobial agents with Docking design, and Energy gap estimation

SA Hassan, JB Ziwar, D muhammed Aziz… - Journal of Molecular …, 2024 - Elsevier
Thiazolidin-4-ones have important biological features, which has led to the development of
new derivatives employing an efficient ultrasonic method. Schiff base derivatives were …

Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance

RH Abd El-Aleam, RF George, HH Georgey… - RSC …, 2021 - pubs.rsc.org
Antibiotic resistance is one of the most important challenges of the 21st century. However,
the growing understanding of bacterial pathogenesis and cell-to-cell communication has …

New benzothiazole-based thiazolidinones as potent antimicrobial agents. Design, synthesis and biological evaluation

M Haroun, C Tratrat, K Kositzi, E Tsolaki… - Current topics in …, 2018 - ingentaconnect.com
Background: Thiazole and benzothiazole derivatives, as well as thiazolidinones are very
important scaffolds in medicinal chemistry. Literature has revealed that they possess a wide …

Identification of novel 4-thiazolidinones as new TcaR inhibitors: Design, synthesis, molecular docking, MD simulation, ADMET and in vitro antibacterial evaluation

MD Vaghasiya, JV Mendapara, SP Vaghasiya… - Journal of Molecular …, 2023 - Elsevier
Novel morpholine and piperazine-containing 4-thiazolidinone derivatives (6a-6e) and (7a-
7e) were designed and synthesized utilizing a multi-component reaction (MCR) to develop …

Novel N-methylsulfonyl-indole derivatives: biological activity and COX-2/5-LOX inhibitory effect with improved gastro protective profile and reduced cardio vascular …

JN Philoppes, MA Abdelgawad… - Journal of Enzyme …, 2023 - Taylor & Francis
Three novel series of N-methylsulfonylindole derivatives 3a&b, 4a–e, and 5a–e were
synthesised. Different biological activities of the synthesised compounds were studied …

New Substituted 5-Benzylideno-2-Adamantylthiazol[3,2-b][1,2,4]Triazol-6(5H)ones as Possible Anti-Inflammatory Agents

C Tratrat, M Haroun, A Paparisva, C Kamoutsis… - Molecules, 2021 - mdpi.com
Background: Inflammation is a complex response to noxious stimuli promoted by the release
of chemical mediators from the damaged cells. Metabolic products of arachidonic acid …