Mitochondria are one of the most important organelles in cells. Mitochondria are semi-
autonomous organelles with their own genetic system, and can independently replicate …

Mitochondria control life and death in eukaryotic cells. Harboring a unique circular genome,
a by‐product of an ancient endosymbiotic event, mitochondria maintains a specialized and …

Translation of mitochondrial messenger RNA (mt-mRNA) is performed by distinct
mitoribosomes comprising at least 36 mitochondria-specific proteins. How these …

Ribosome biogenesis requires auxiliary factors to promote folding and assembly of
ribosomal proteins and RNA. Particularly, maturation of the peptidyl transferase center (PTC) …

The mitochondrial translation system originates from a bacterial ancestor but has
substantially diverged in the course of evolution. Here, we use single-particle cryo-electron …

Assembly of the mitoribosome is largely enigmatic and involves numerous assembly factors.
Little is known about their function and the architectural transitions of the pre-ribosomal …

Protein synthesis by the ribosome requires large-scale rearrangements of the 'small'subunit
(SSU;∼ 1 MDa), including inter-and intra-subunit rotational motions. However, with nearly …

The mammalian mitochondrial ribosome (mitoribosome) and its associated translational
factors have evolved to accommodate greater participation of proteins in mitochondrial …

Translation and ribosome biogenesis in mitochondria require auxiliary factors that ensure
rapid and accurate synthesis of mitochondrial proteins. Defects in translation are associated …

Mitochondrial DNA (mtDNA) has an important yet often overlooked role in health and
disease. Constraint models quantify the removal of deleterious variation from the population …