Metal-based G-quadruplex binders for cancer theranostics
The ability of fluorescent small molecules, such as metal complexes, to selectively recognize
G-quadruplex (G4) structures has opened a route to develop new probes for the …
G-quadruplex (G4) structures has opened a route to develop new probes for the …
Evaluation of acridine orange derivatives as DNA-targeted radiopharmaceuticals for Auger therapy: influence of the radionuclide and distance to DNA
A new family of 99mTc (I)-tricarbonyl complexes and 125I-heteroaromatic compounds
bearing an acridine orange (AO) DNA targeting unit was evaluated for Auger therapy …
bearing an acridine orange (AO) DNA targeting unit was evaluated for Auger therapy …
Anticancer activity of structurally related ruthenium (II) cyclopentadienyl complexes
A set of structurally related Ru (η 5-C 5 H 5) complexes with bidentate N, N′-
heteroaromatic ligands have been evaluated as prospective metallodrugs, with focus on …
heteroaromatic ligands have been evaluated as prospective metallodrugs, with focus on …
Evaluation of cellular uptake, cytotoxicity and cellular ultrastructural effects of heteroleptic oxidovanadium (IV) complexes of salicylaldimines and polypyridyl ligands
Searching for prospective vanadium-based drugs for cancer treatment, a new series of
structurally related [V IV O (L− 2H)(NN)] compounds (1–8) was developed. They include a …
structurally related [V IV O (L− 2H)(NN)] compounds (1–8) was developed. They include a …
Polymer “ruthenium-cyclopentadienyl” conjugates-New emerging anti-cancer drugs
In this work, we aimed to understand the biological activity and the mechanism of action of
three polymer-'ruthenium-cyclopentadienyl'conjugates (RuPMC) and a low molecular weight …
three polymer-'ruthenium-cyclopentadienyl'conjugates (RuPMC) and a low molecular weight …
The key role of coligands in novel ruthenium (II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds
A new family of eight ruthenium (II)-cyclopentadienyl bipyridine derivatives, bearing
nitrogen, sulfur, phosphorous and carbonyl sigma bonded coligands, has been synthesized …
nitrogen, sulfur, phosphorous and carbonyl sigma bonded coligands, has been synthesized …
Cellular uptake mechanisms of an antitumor ruthenium compound: The endosomal/lysosomal system as a target for anticancer metal-based drugs
Previous studies have described promising antitumor activity of an organometallic Ru (II)
complex, η5-Cyclopentadienyl (2, 2′-bipyridyl)(triphenylphosphane) Ruthenium (II) triflate …
complex, η5-Cyclopentadienyl (2, 2′-bipyridyl)(triphenylphosphane) Ruthenium (II) triflate …
Synthesis and Biological Evaluation of Novel 2‐Aryl Benzimidazoles as Chemotherapeutic Agents
Here, we describe the synthesis and preliminary biological evaluation of novel N‐
unsubstituted and N‐methylated 2‐aryl benzimidazole derivatives that contain fluorinated or …
unsubstituted and N‐methylated 2‐aryl benzimidazole derivatives that contain fluorinated or …
Insight into the cytotoxicity of polynuclear Cu (I) camphor complexes
Three new polynuclear Cu (I) camphor complexes,[(CuBr) 2 {(pH 2 NC 6 H 4) NC 10 H 14
O}] n (2d),[(CuCl) 4 {mC 6 H 4 (NC 10 H 14 O) 2}] n (5f) and [(CuBr) 4 {pC 6 H 4 (NC 10 H 14 …
O}] n (2d),[(CuCl) 4 {mC 6 H 4 (NC 10 H 14 O) 2}] n (5f) and [(CuBr) 4 {pC 6 H 4 (NC 10 H 14 …
Design and biological evaluation of new platinum (II) complexes bearing ligands with DNA-targeting ability
A novel series of platinum (II) complexes bearing aliphatic amines and ligands with DNA-
targeting properties was synthesized to achieve more potent and selective metallodrugs. We …
targeting properties was synthesized to achieve more potent and selective metallodrugs. We …