Publisher Summary This chapter discusses the role played by protein phosphorylation in the
control of translation. Research has continued to center on its role in the regulation of …

Publisher Summary This chapter describes the regulation of initiation of mammalian protein
synthesis. It discusses the current knowledge of the initiation of protein synthesis. The …

We have investigated the action of insulin on protein turnover in heart, skeletal muscle and
liver. Protein turnover in heart is obviously important for the survival of the organism. Protein …

Eukaryotic translation initiation factor 2 (eIF2) is a heterotrimeric GTPase, which plays a
critical role in protein synthesis regulation. eIF2-GTP binds Met-tRNAi to form the eIF2-GTP• …

Large-scale purification of translational inhibitors present in interferon-treated mouse L cells,
but not in untreated cells, led to the isolation of two interferon-induced activities. One is a …

Earlier, we isolated eukaryotic initiation factor 2 (eIF-2)-stimulating protein (SP) as a
homogeneous complex with eIF-2 (eIF-2-SP) and showed that, in the presence of Mg2+, eIF …

The expression of genetic information in both procaryotes and eucaryotes is controlled to a
large extent at the transcriptional level, ie, at the level of gene-directed synthesis of mRNA …

Oxidized glutathione (GSSG)(0.02-0.5 mM) inhibits reticulocyte lysates by a mechanism
similar to that observed in heme deficiency. Incubation of hemin-supplemented …

Mutation at the GLC1 locus in Saccharomyces cerevisiae resulted in simultaneous
deficiencies in glycogen and trehalose accumulation. Extracts of yeast cells containing the …

Catalysis of ternary complex formation by the GDP exchange factor (GEF), in the presence of
Mg2+, is blocked by phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 …