The identification of key genes in transcriptomic data constitutes a huge challenge. Our
review of microarray reports revealed 88 genes whose transcription is consistently regulated …

Krüppel-like factors (KLFs) are a family of zinc-finger transcription factors that are found in
many species. Recent studies have shown that KLFs play a fundamental role in regulating …

Rationale: Severe asthma (SA) is a heterogeneous disease with multiple molecular
mechanisms. Gene expression studies of bronchial epithelial cells in individuals with …

Stressful events evoke long-term changes in behavioral responses; however, the underlying
mechanisms in the brain are not well understood. Previous work has shown that epigenetic …

The hypothalamic–pituitary–adrenal axis is an extremely dynamic system with a
combination of both circadian and ultradian oscillations. This state of 'continuous dynamic …

Chronic stress is a risk factor for several neuropsychiatric diseases, such as depression and
psychosis. In response to stress glucocorticoids (GCs) are secreted that bind to …

Nutrient handling by higher organisms is a complex process that is regulated at the
transcriptional level. Studies over the past 15 years have highlighted the critical importance …

In the present study, genomic binding sites of glucocorticoid receptors (GR) were identified
in vivo in the rat hippocampus applying chromatin immunoprecipitation followed by next …

Gastric cancer (GC) is among the most lethal human malignancies, and the leading cause of
GC mortality is metastasis. However, the precise mechanism of GC metastasis remains …

The glucocorticoid receptor (GR) regulates adaptive transcriptional programs that alter
metabolism in response to stress. Network properties that allow GR to tune gene expression …