Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II–
peptide complexes to control phagosomal infections, help B cells, regulate tissue …

Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases …

Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …

Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …

Co-infection with Mycobacterium tuberculosis is the leading cause of death in individuals
infected with HIV-1. It has long been known that HIV-1 infection alters the course of M …

In the quest for a functional cure or the eradication of HIV infection, it is necessary to know
the sizes of the reservoirs from which infection rebounds after treatment interruption. Thus …

Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …

Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from
infected cells and tissues. Here, sequential long-acting slow-effective release antiviral …

Host proteins are essential for HIV entry and replication and can be important nonviral
therapeutic targets. Large-scale RNA interference (RNAi)-based screens have identified …

BACKGROUND Understanding HIV dynamics across the human body is important for cure
efforts. This goal has been hampered by technical difficulties and the challenge of obtaining …