The carboxy-terminal domain (CTD) extends from the largest subunit of RNA polymerase II
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …

Chromatin is a dynamic structure that must respond to myriad stimuli to regulate access to
DNA, and chemical modification of histones is a major means by which the cell modulates …

The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …

The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic
stability. Indeed, this methylation mark is essential for proper transcription, recombination …

The regulation of transcription by RNA polymerase II is closely intertwined with the
regulation of chromatin structure. A host of proteins required for the disassembly …

Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …

Set2-mediated methylation of histone H3 at Lys 36 (H3K36me) is a co-transcriptional event
that is necessary for the activation of the Rpd3S histone deacetylase complex, thereby …

Set2-mediated methylation of histone H3 Lys36 (H3K36) is a mark associated with the
coding sequences of actively transcribed genes, but it has a negative role during …

Covalent modifications of histone proteins play key roles in transcription, DNA repair,
recombination, and other such processes. Over a hundred histone modifications have been …