R-loops are three-stranded nucleic acid structures that are abundant and widespread across
the genome and that have important physiological roles in many nuclear processes. Their …

The Wnt signaling pathway is a highly conserved regulator of metazoan development and
stem cell maintenance. Activation of Wnt signaling is an early step in diverse malignancies …

High-throughput imaging (HTI) generates complex imaging datasets from a large number of
experimental perturbations. Commercial HTI software programs for image analysis …

Correct organization of higher-order genome folding is essential for the regulation of gene
expression, DNA replication and other genomic functions. Technological advances in high …

The last two decades of work on chromosome conformation in eukaryotic nuclei have
revealed a complex and highly regulated hierarchy of architectural features, from self …

The association of genomic loci to the nuclear periphery is proposed to facilitate cell type-
specific gene repression and influence cell fate decisions. However, the interplay between …

The relationship between cohesin-mediated chromatin loo** and gene expression
remains unclear. NIPBL and WAPL are two opposing regulators of cohesin activity; …

Nuclear organization has emerged as a potential key regulator of genome function. During
development, the deployment of transcriptional programs must be tightly coordinated with …

Non-homologous chromosomal contacts (NHCCs) between different chromosomes
participate considerably in gene and genome regulation. Due to analytical challenges …

The mystery of how human DNA is compactly packaged into a nucleus—a space a hundred
thousand times smaller—while still allowing for the regulation of gene function, has long …