Haemodynamic forces influence the functional properties of vascular endothelium.
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …

In addition to biochemical gradients and transcriptional networks, cell behavior is regulated
by endogenous bioelectrical cues originating in the activity of ion channels and pumps …

A major goal of regenerative medicine and bioengineering is the regeneration of complex
organs, such as limbs, and the capability to create artificial constructs (so-called biobots) …

This review places modern research developments in vascular mechanobiology in the
context of hemodynamic phenomena in the cardiovascular system and the discrete …

As manipulation of gene expression by virtue of microRNAs (miRNAs) is one of the
emerging strategies for cardiovascular disease remedy, local delivery of miRNAs to a …

Significance: Changes in shear stress associated with alterations in blood flow initiate a
signaling cascade that modulates the vascular phenotype. Shear stress is “sensed” by the …

Mechanotransduction is a process where cells sense their surroundings and convert the
physical forces in their environment into an appropriate response. Calcium plays a crucial …

Implants, including artificial joints, bone fixation devices, and other orthopedic implants, oral
implants, and vascular interventional devices, are used to repair or replace human tissues or …

Regeneration of damaged body parts requires coordination of size, shape, location and
orientation of tissue with the rest of the body. It is not currently known to what extent injury …

Vascular calcification (VC) is characterized by pathological depositions of calcium and
phosphate in the arteries and veins via an active cell-regulated process, in which vascular …