Plasmodium species: master renovators of their host cells

TF de Koning-Ward, MWA Dixon, L Tilley… - Nature Reviews …, 2016 - nature.com
Plasmodium parasites, the causative agents of malaria, have developed elaborate
strategies that they use to survive and thrive within different intracellular environments …

How malaria parasites acquire nutrients from their host

NA Counihan, JK Modak… - Frontiers in Cell and …, 2021 - frontiersin.org
Plasmodium parasites responsible for the disease malaria reside within erythrocytes. Inside
this niche host cell, parasites internalize and digest host hemoglobin to source amino acids …

A proteomic view of the Plasmodium falciparum life cycle

L Florens, MP Washburn, JD Raine, RM Anthony… - Nature, 2002 - nature.com
The completion of the Plasmodium falciparum clone 3D7 genome provides a basis on which
to conduct comparative proteomics studies of this human pathogen. Here, we applied a high …

Discovery of gene function by expression profiling of the malaria parasite life cycle

KG Le Roch, Y Zhou, PL Blair, M Grainger, JK Moch… - Science, 2003 - science.org
The completion of the genome sequence for Plasmodium falciparum, the species
responsible for most malaria human deaths, has the potential to reveal hundreds of new …

[HTML][HTML] Malaria parasite clag3 genes determine channel-mediated nutrient uptake by infected red blood cells

W Nguitragool, AAB Bokhari, AD Pillai, K Rayavara… - Cell, 2011 - cell.com
Development of malaria parasites within vertebrate erythrocytes requires nutrient uptake at
the host cell membrane. The plasmodial surface anion channel (PSAC) mediates this …

The malaria-infected red blood cell: structural and functional changes

BM Cooke, N Mohandas, RL Coppel - 2001 - Elsevier
The asexual stage of malaria parasites of the genus Plasmodium invade red blood cells of
various species including humans. After parasite invasion, red blood cells progressively …

The pathophysiology of falciparum malaria

IA Clark, WB Cowden - Pharmacology & therapeutics, 2003 - Elsevier
Falciparum malaria is a complex disease with no simple explanation, affecting organs where
the parasite is rare as well as those organs where it is more common. We continue to argue …

Virulence in malaria: an evolutionary viewpoint

MJ Mackinnon, AF Read - Philosophical Transactions of …, 2004 - royalsocietypublishing.org
Malaria parasites cause much morbidity and mortality to their human hosts. From our
evolutionary perspective, this is because virulence is positively associated with parasite …

Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

NA Counihan, SA Chisholm, HE Bullen, A Srivastava… - Elife, 2017 - elifesciences.org
Plasmodium falciparum parasites, the causative agents of malaria, modify their host
erythrocyte to render them permeable to supplementary nutrient uptake from the plasma and …

Widespread functional specialization of Plasmodium falciparum erythrocyte membrane protein 1 family members to bind CD36 analysed across a parasite genome

BA Robinson, TL Welch, JD Smith - Molecular microbiology, 2003 - Wiley Online Library
Plasmodium falciparum‐infected erythrocytes sequester from blood circulation by binding
host endothelium. A large family of variant proteins mediates cytoadherence and their …