Traumatic brain injury (TBI) is an important global health concern that represents a leading
cause of death and disability. It occurs due to direct impact or hit on the head caused by …

The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for
malaria therapy, but its bioactivity spectrum is much broader. In this review, we give a …

Liver fibrosis is a progression of chronic liver disease, which lacks effective therapies in the
world. Attractively, more and more evidences show that natural products are safe and …

A transcriptional regulatory nuclear factor kappa B (NF-ΚB) protein is a modulator of cellular
biological activity via binding to a promoter region in the nucleus and transcribing various …

Traumatic brain injury is one of the leading causes of mortality and morbidity in the world
with no current pharmacological treatment. The role of BDNF in neural repair and …

Highlights•Natural products show great promises in the drug repositioning campaign.•New
drug-disease associations are uncovered and discussed.•Pros and cons in natural product …

Ischemia/reperfusion (I/R) injury is a pathological process wherein reperfusion of an
ischemic organ or tissue exacerbates the injury, posing a significant health threat and …

Abstract Irinotecan (CPT-11) is a topoisomerase I inhibitor that was approved for cancer
treatment in 1994. To date, this natural product derivative remains the world's leading …

Alzheimer's disease (AD) is the principal cause of dementia, and its incidence increases
with age. Altered antioxidant systems and inflammation have an important role in the …

Vascular dementia (VaD) is the second leading cause of dementia. The majority of VaD
patients have cognitive abnormalities, which are caused by cerebral hypoperfusion-induced …