Sepsis-induced AKI: From pathogenesis to therapeutic approaches
FF He, YM Wang, YY Chen, W Huang, ZQ Li… - Frontiers in …, 2022 - frontiersin.org
Sepsis is a heterogenous and highly complex clinical syndrome, which is caused by
infectious or noninfectious factors. Acute kidney injury (AKI) is one of the most common and …
infectious or noninfectious factors. Acute kidney injury (AKI) is one of the most common and …
Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders
Neuroinflammatory disorders preferentially impair the higher cognitive and executive
functions of the prefrontal cortex (PFC). This includes such challenging disorders as …
functions of the prefrontal cortex (PFC). This includes such challenging disorders as …
Autonomic and circulatory alterations persist despite adequate resuscitation in a 5-day sepsis swine experiment
Autonomic and vascular failures are common phenotypes of sepsis, typically characterized
by tachycardia despite corrected hypotension/hypovolemia, vasopressor resistance …
by tachycardia despite corrected hypotension/hypovolemia, vasopressor resistance …
[HTML][HTML] Dexmedetomidine post-treatment exacerbates metabolic disturbances in septic cardiomyopathy via α2A-adrenoceptor
Y Xu, X Zhang, X Tang, C Zhang, JG Cahoon… - Biomedicine & …, 2024 - Elsevier
Cardiomyopathy is a common complication and significantly increases the risk of death in
septic patients. Our previous study demonstrated that post-treatment with dexmedetomidine …
septic patients. Our previous study demonstrated that post-treatment with dexmedetomidine …
Dexmedetomidine ameliorates acute brain injury induced by myocardial ischemia-reperfusion via upregulating the HIF-1 pathway
X Yang, J Wu, H Cheng, S Chen, J Wang - Shock, 2023 - journals.lww.com
Objective: Neurological complications after myocardial ischemia/reperfusion (IR) injury
remain high and seriously burden patients and their families. Dexmedetomidine (Dex), an α …
remain high and seriously burden patients and their families. Dexmedetomidine (Dex), an α …
Posttreatment with dexmedetomidine aggravates LPS-induced myocardial dysfunction partly via activating cardiac endothelial α2A-AR in mice
X Tang, C Zhang, T Tian, X Dai, Y **ng, Y Wang… - International …, 2023 - Elsevier
Background Dexmedetomidine (DEX) administered before or at 30 min after sepsis
induction was reported to alleviate septic cardiomyopathy in experimental models. However …
induction was reported to alleviate septic cardiomyopathy in experimental models. However …
Dexmedetomidine on the interplay of IL-6 and STAT3 pathways in adrenal gland damage-induced scalding burns in rats
Scalding burns are a common form of thermal injury that often leads to systemic
complications. Pro-inflammatory cytokines like interleukin-6 (IL-6) and the activation of …
complications. Pro-inflammatory cytokines like interleukin-6 (IL-6) and the activation of …
The selectivity of α‐adrenoceptor agonists for the human α1A, α1B, and α1D‐adrenoceptors
RGW Proudman, JG Baker - Pharmacology Research & …, 2021 - Wiley Online Library
Highly selective drugs offer a way to minimize side‐effects. For agonist ligands, this could be
through highly selective affinity or highly selective efficacy, but this requires careful …
through highly selective affinity or highly selective efficacy, but this requires careful …
Activating astrocytic α2A adrenoceptors in hippocampus reduces glutamate toxicity to attenuate sepsis-associated encephalopathy in mice
B Mei, X Xu, J Weng, Y Yang, P Wang, G Qiu… - Brain, Behavior, and …, 2024 - Elsevier
Background Glutamate metabolism disorder is an important mechanism of sepsis-
associated encephalopathy (SAE). Astrocytes regulate glutamate metabolism. In septic …
associated encephalopathy (SAE). Astrocytes regulate glutamate metabolism. In septic …
Effects of dexmedetomidine on kidney and brain tissue microcirculation and histology in ovine cardiopulmonary bypass: a randomised controlled trial
Cardiac surgery requiring cardiopulmonary bypass is associated with postoperative acute
kidney injury and neurocognitive disorders, including delirium. Intra‐operative inflammation …
kidney injury and neurocognitive disorders, including delirium. Intra‐operative inflammation …