Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Skin aging is one of the most evident signs of human aging. Modification of the skin during
the life span is characterized by fine lines and wrinkling, loss of elasticity and volume, laxity …

Astragalus membranaceus Bunge has been used to treat numerous diseases for thousands
of years. As the main active substance of Astragalus membranaceus Bunge, astragaloside …

Everyone knows and seems to agree that melanocytes are there to generate melanin–an
intriguing, but underestimated multipurpose molecule that is capable of doing far more than …

Neuromelanin (NM) is a dark polymer pigment produced in specific populations of
catecholaminergic neurons in the brain. It appears in greatest quantities in the human brain …

The mammalian hair follicle represents a unique, highly regenerative neuroectodermal-
mesodermal interaction system that contains numerous stem cells. It is the only organ in the …

In horses, graying with age is an autosomal dominant trait associated with a high incidence
of melanoma and vitiligo-like depigmentation. Here we show that the Gray phenotype is …

Oxidative stress is generated by a multitude of environmental and endogenous challenges
such as radiation, inflammation, or psychoemotional stress. It also speeds the aging …

Experimental evidence supports the hypothesis that oxidative stress plays a major role in the
ageing process. Reactive oxygen species are generated by a multitude of endogenous and …

Bioinspired nanomaterials are ideal components for nanomedicine, by virtue of their
expected biocompatibility or even complete lack of toxicity. Natural and artificial melanin …