Severe childhood malnutrition

ZA Bhutta, JA Berkley, RHJ Bandsma… - Nature reviews Disease …, 2017 - nature.com
The main forms of childhood malnutrition occur predominantly in children< 5 years of age
living in low-income and middle-income countries and include stunting, wasting and …

[HTML][HTML] Nonalcoholic fatty liver disease and the gut-liver axis: exploring an undernutrition perspective

KC Bauer, PT Littlejohn, V Ayala, A Creus-Cuadros… - Gastroenterology, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is a chronic condition affecting one quarter of the
global population. Although primarily linked to obesity and metabolic syndrome …

Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance

GA Preidis, KH Kim, DD Moore - The Journal of clinical investigation, 2017 - jci.org
The nuclear receptors PPARα (encoded by NR1C1) and farnesoid X receptor (FXR,
encoded by NR1H4) are activated in the liver in the fasted and fed state, respectively …

Physiological activation of human and mouse bitter taste receptors by bile acids

F Ziegler, A Steuer, A Di Pizio, M Behrens - Communications Biology, 2023 - nature.com
Beside the oral cavity, bitter taste receptors are expressed in several non-gustatory tissues.
Whether extra-oral bitter taste receptors function as sensors for endogenous agonists is …

Fibroblast growth factor 15/19: from basic functions to therapeutic perspectives

E Somm, FR Jornayvaz - Endocrine reviews, 2018 - academic.oup.com
Discovered 20 years ago, fibroblast growth factor (FGF) 19, and its mouse ortholog FGF15,
were the first members of a new subfamily of FGFs able to act as hormones. During fetal life …

Current understanding of innate immune cell dysfunction in childhood undernutrition

CD Bourke, KDJ Jones, AJ Prendergast - Frontiers in immunology, 2019 - frontiersin.org
Undernutrition affects millions of children in low-and middle-income countries (LMIC) and
underlies almost half of all deaths among children under 5 years old. The growth deficits that …

Inflammation‐induced cholestasis in cancer cachexia

MM Thibaut, M Sboarina, M Roumain… - Journal of cachexia …, 2021 - Wiley Online Library
Background Cancer cachexia is a debilitating metabolic syndrome contributing to cancer
death. Organs other than the muscle may contribute to the pathogenesis of cancer cachexia …

Gut microbiota and childhood malnutrition: Understanding the link and exploring therapeutic interventions

S Zoghi, F Sadeghpour Heravi… - Engineering in Life …, 2024 - Wiley Online Library
Childhood malnutrition is a metabolic condition that affects the physical and mental well‐
being of children and leads to resultant disorders in maturity. The development of childhood …

Mechanisms of cross-talk between the diet, the intestinal microbiome, and the undernourished host

H Velly, RA Britton, GA Preidis - Gut microbes, 2017 - Taylor & Francis
Undernutrition remains one of the most pressing global health challenges today,
contributing to nearly half of all deaths in children under five years of age. Although …

A saliva-based rapid test to quantify the infectious subclinical malaria parasite reservoir

D Tao, B McGill, T Hamerly, T Kobayashi… - Science translational …, 2019 - science.org
A large proportion of ongoing malaria parasite transmission is attributed to low-density
subclinical infections not readily detected by available rapid diagnostic tests (RDTs) or …