Role of monoamine oxidase activity in Alzheimer's disease: an insight into the therapeutic potential of inhibitors
T Behl, D Kaur, A Sehgal, S Singh, N Sharma… - Molecules, 2021 - mdpi.com
Despite not being utilized as considerably as other antidepressants in the therapy of
depression, the monoamine oxidase inhibitors (MAOIs) proceed to hold a place in …
depression, the monoamine oxidase inhibitors (MAOIs) proceed to hold a place in …
Therapeutic targets in lung tissue remodelling and fibrosis
Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
Necroptosis signaling promotes inflammation, airway remodeling, and emphysema in chronic obstructive pulmonary disease
Z Lu, HP Van Eeckhoutte, G Liu, PM Nair… - American journal of …, 2021 - atsjournals.org
Rationale: Necroptosis, mediated by RIPK3 (receptor-interacting protein kinase 3) and
MLKL (mixed lineage kinase domain-like), is a form of regulated necrosis that can drive …
MLKL (mixed lineage kinase domain-like), is a form of regulated necrosis that can drive …
A microRNA-21–mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis
Chronic obstructive pulmonary disease (COPD) is the third leading cause of morbidity and
death worldwide. Inhalation of cigarette smoke (CS) is the major cause in developed …
death worldwide. Inhalation of cigarette smoke (CS) is the major cause in developed …
Microbiome effects on immunity, health and disease in the lung
Chronic respiratory diseases, including asthma, chronic obstructive pulmonary disease
(COPD) and cystic fibrosis (CF), are among the leading causes of mortality and morbidity …
(COPD) and cystic fibrosis (CF), are among the leading causes of mortality and morbidity …
The race to bash NASH: emerging targets and drug development in a complex liver disease
FA Romero, CT Jones, Y Xu, M Fenaux… - Journal of medicinal …, 2020 - ACS Publications
Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease
(NAFLD) characterized by liver steatosis, inflammation, and hepatocellular damage. NASH …
(NAFLD) characterized by liver steatosis, inflammation, and hepatocellular damage. NASH …
A randomised Phase IIa trial of amine oxidase copper-containing 3 (AOC3) inhibitor BI 1467335 in adults with non-alcoholic steatohepatitis
Non-alcoholic steatohepatitis (NASH) is a progressive, inflammatory liver disease with no
approved pharmacological treatment. This Phase IIa, double-blind, placebo-controlled …
approved pharmacological treatment. This Phase IIa, double-blind, placebo-controlled …
TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase
Abstract Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded
RNA viruses, and is increased in both human and cigarette smoke (CS)-induced …
RNA viruses, and is increased in both human and cigarette smoke (CS)-induced …
Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin‐1c
Asthma is a chronic inflammatory disease of the airways. It is characterized by allergic
airway inflammation, airway remodelling, and airway hyperresponsiveness (AHR). Asthma …
airway inflammation, airway remodelling, and airway hyperresponsiveness (AHR). Asthma …
Hypoxia‐inducible factor and bacterial infections in chronic obstructive pulmonary disease
ABSTRACT COPD is a seriously disabling respiratory condition that inexorably progresses
to disability and mortality. It affects approximately 10% of the population globally with a …
to disability and mortality. It affects approximately 10% of the population globally with a …