Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …

Metabolic reprogramming enables cancer cell growth, proliferation, and survival. This
reprogramming is driven by the combined actions of oncogenic alterations in cancer cells …

Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole …

Cancers emerge from an ongoing Darwinian evolutionary process, often leading to multiple
competing subclones within a single primary tumour,,,. This evolutionary process culminates …

The androgen-signaling axis plays a pivotal role in the pathogenesis of prostate cancer.
Since the landmark discovery by Huggins and Hodges, gonadal depletion of androgens has …

Tumour hypoxia is increasingly recognized as a major deleterious factor in cancer therapies,
as it compromises treatment and drives malignant progression. This review seeks to clarify …

The recent outbreak of infections and the pandemic caused by SARS-CoV-2 represent one
of the most severe threats to human health in more than a century. Emerging data from the …

Master transcription factors interact with DNA to establish cell type identity and to regulate
gene expression in mammalian cells,. The genome-wide map of these transcription factor …

Genome-wide association studies (GWAS) have identified 76 variants associated with
prostate cancer risk predominantly in populations of European ancestry. To identify …

We demonstrate that the androgen receptor (AR) regulates a transcriptional program of DNA
repair genes that promotes prostate cancer radioresistance, providing a potential …