Mechanisms underlying mutational signatures in human cancers
The collective somatic mutations observed in a cancer are the outcome of multiple
mutagenic processes that have been operative over the lifetime of a patient. Each process …
mutagenic processes that have been operative over the lifetime of a patient. Each process …
[HTML][HTML] APOBECs and virus restriction
RS Harris, JP Dudley - Virology, 2015 - Elsevier
The APOBEC family of single-stranded DNA cytosine deaminases comprises a formidable
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA
J Lucifora, Y **a, F Reisinger, K Zhang, D Stadler… - Science, 2014 - science.org
Current antiviral agents can control but not eliminate hepatitis B virus (HBV), because HBV
establishes a stable nuclear covalently closed circular DNA (cccDNA). Interferon-α treatment …
establishes a stable nuclear covalently closed circular DNA (cccDNA). Interferon-α treatment …
The APOBEC protein family: united by structure, divergent in function
JD Salter, RP Bennett, HC Smith - Trends in biochemical sciences, 2016 - cell.com
The APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) family of proteins
have diverse and important functions in human health and disease. These proteins have an …
have diverse and important functions in human health and disease. These proteins have an …
Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B
K Shi, MA Carpenter, S Banerjee, NM Shaban… - Nature structural & …, 2017 - nature.com
APOBEC-catalyzed cytosine-to-uracil deamination of single-stranded DNA (ssDNA) has
beneficial functions in immunity and detrimental effects in cancer. APOBEC enzymes have …
beneficial functions in immunity and detrimental effects in cancer. APOBEC enzymes have …
The topography of mutational processes in breast cancer genomes
Somatic mutations in human cancers show unevenness in genomic distribution that
correlate with aspects of genome structure and function. These mutations are, however …
correlate with aspects of genome structure and function. These mutations are, however …
APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages
S Sharma, SK Patnaik, R Thomas Taggart… - Nature …, 2015 - nature.com
The extent, regulation and enzymatic basis of RNA editing by cytidine deamination are
incompletely understood. Here we show that transcripts of hundreds of genes undergo site …
incompletely understood. Here we show that transcripts of hundreds of genes undergo site …
DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers
Certain mutagens, including the APOBEC3 (A3) cytosine deaminase enzymes, can create
multiple genetic changes in a single event. Activity of A3s results in striking 'mutation …
multiple genetic changes in a single event. Activity of A3s results in striking 'mutation …
Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer
The somatic mutations in a cancer genome are the aggregate outcome of one or more
mutational processes operative through the lifetime of the individual with cancer,,. Each …
mutational processes operative through the lifetime of the individual with cancer,,. Each …
Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all
BA Desimmie, KA Delviks-Frankenberrry… - Journal of molecular …, 2014 - Elsevier
Several members of the APOBEC3 family of cellular restriction factors provide intrinsic
immunity to the host against viral infection. Specifically, APOBEC3DE, APOBEC3F …
immunity to the host against viral infection. Specifically, APOBEC3DE, APOBEC3F …