The blood-brain barrier in aging and neurodegeneration
The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an
exquisite control of exchange of compounds between the blood and the brain parenchyma …
exquisite control of exchange of compounds between the blood and the brain parenchyma …
Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches
Y **, W Ji, H Yang, S Chen, W Zhang… - Signal transduction and …, 2020 - nature.com
On 12 March 2020, the outbreak of coronavirus disease 2019 (COVID-19) was declared a
pandemic by the World Health Organization. As of 4 August 2020, more than 18 million …
pandemic by the World Health Organization. As of 4 August 2020, more than 18 million …
Precision drug delivery to the central nervous system using engineered nanoparticles
Abstract Development of novel therapies for central nervous system (CNS) disorders has
experienced a high failure rate in clinical trials owing to unsatisfactory efficacy and adverse …
experienced a high failure rate in clinical trials owing to unsatisfactory efficacy and adverse …
Role of angiopoietin-2 in vascular physiology and pathophysiology
Angiopoietins 1–4 (Ang1–4) represent an important family of growth factors, whose activities
are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized …
are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized …
Brain microvascular pericytes in vascular cognitive impairment and dementia
Pericytes are unique, multi-functional mural cells localized at the abluminal side of the
perivascular space in microvessels. Originally discovered in 19th century, pericytes had …
perivascular space in microvessels. Originally discovered in 19th century, pericytes had …
[HTML][HTML] Reactive astrocytes: The nexus of pathological and clinical hallmarks of Alzheimer's disease
BR Price, LA Johnson, CM Norris - Ageing research reviews, 2021 - Elsevier
Astrocyte reactivity is a hallmark of neuroinflammation that arises with Alzheimer's disease
(AD) and nearly every other neurodegenerative condition. While astrocytes certainly …
(AD) and nearly every other neurodegenerative condition. While astrocytes certainly …
Tumor-derived small extracellular vesicles in cancer invasion and metastasis: molecular mechanisms, and clinical significance
C Zhang, C Qin, S Dewanjee, H Bhattacharya… - Molecular Cancer, 2024 - Springer
The production and release of tumor-derived small extracellular vesicles (TDSEVs) from
cancerous cells play a pivotal role in the propagation of cancer, through genetic and …
cancerous cells play a pivotal role in the propagation of cancer, through genetic and …
The neurovascular unit: effects of brain insults during the perinatal period
The neurovascular unit (NVU) is a relatively recent concept in neuroscience that broadly
describes the relationship between brain cells and their blood vessels. The NVU …
describes the relationship between brain cells and their blood vessels. The NVU …
Role of pericytes in blood–brain barrier preservation during ischemia through tunneling nanotubes
Crosstalk mechanisms between pericytes, endothelial cells, and astrocytes preserve
integrity and function of the blood-brain-barrier (BBB) under physiological conditions. Long …
integrity and function of the blood-brain-barrier (BBB) under physiological conditions. Long …
Effects of choline containing phospholipids on the neurovascular unit: A review
The roles of choline and of choline-containing phospholipids (CCPLs) on the maintenance
and progress of neurovascular unit (NVU) integrity are analyzed. NVU is composed of …
and progress of neurovascular unit (NVU) integrity are analyzed. NVU is composed of …