Treatment of cancer with chemo-or radiotherapy causes reduction of sperm counts often to
azoospermic levels that may persist for several years or be permanent. The time course of …

BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

Background Few data define the dose-specific relation between alkylating agent exposure
and semen variables in adult survivors of childhood cancer. We undertook this study to test …

Estimates suggest that by 2010, one in 715 people in the UK will have survived cancer
during childhood. With increasing numbers of children cured, attention has focused on their …

The alkylating agent busulfan (Myleran) adversely affects spermatogenesis in mammals. We
treated male mice with single doses of busulfan in order to quantitate its cytotoxic action on …

There is growing concern that some cytotoxic regimens for cancer adversely affect
spermatogenesis and male fertility. Increasing evidence demonstrated that melatonin has …

Introduction T HE REGULARITY of gonadal dysfunction in patients with chronic renal failure
and in particular the dramatic reversal of hypogonadism after successful renal …

The gonadal histology of 21 prepubertal, intrapubertal, and postpubertal girls who died 1
day to 2 months after cessation of therapy for extragonadal solid tumors was reviewed. In …

Azoospermia and long-lasting testicular atrophy are common adverse consequences of
cancer treatment. Chemotherapeutic agents may disrupt spermatogenesis by targeting …

The spacial distribution of cell death among the epithelial cells lining the adult mammalian
small intestinal mucosa at various times after a range of doses of 10 different drugs as well …