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Determinants of enhancer and promoter activities of regulatory elements
The proper activities of enhancers and gene promoters are essential for coordinated
transcription within a cell. Although diverse methodologies have been developed to identify …
transcription within a cell. Although diverse methodologies have been developed to identify …
Eukaryotic core promoters and the functional basis of transcription initiation
Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …
transcription start sites of protein-coding and non-coding genes that support the assembly of …
Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation
Precise spatio–temporal control of gene activity is essential for organismal development,
growth, and survival in a changing environment. Decisive steps in gene regulation involve …
growth, and survival in a changing environment. Decisive steps in gene regulation involve …
Structure of paused transcription complex Pol II–DSIF–NELF
Metazoan gene regulation often involves the pausing of RNA polymerase II (Pol II) in the
promoter-proximal region. Paused Pol II is stabilized by the protein complexes DRB …
promoter-proximal region. Paused Pol II is stabilized by the protein complexes DRB …
Causes and consequences of RNA polymerase II stalling during transcript elongation
The journey of RNA polymerase II (Pol II) as it transcribes a gene is anything but a smooth
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …
Evaluating enhancer function and transcription
Cell-type-and condition-specific profiles of gene expression require coordination between
protein-coding gene promoters and cis-regulatory sequences called enhancers. Enhancers …
protein-coding gene promoters and cis-regulatory sequences called enhancers. Enhancers …
Getting up to speed with transcription elongation by RNA polymerase II
Recent advances in sequencing techniques that measure nascent transcripts and that
reveal the positioning of RNA polymerase II (Pol II) have shown that the pausing of Pol II in …
reveal the positioning of RNA polymerase II (Pol II) have shown that the pausing of Pol II in …
Mll3 and Mll4 facilitate enhancer RNA synthesis and transcription from promoters independently of H3K4 monomethylation
KM Dorighi, T Swigut, T Henriques, NV Bhanu… - Molecular cell, 2017 - cell.com
Monomethylation of histone H3 at lysine 4 (H3K4me1) and acetylation of histone H3 at
lysine 27 (H3K27ac) are correlated with transcriptionally engaged enhancer elements, but …
lysine 27 (H3K27ac) are correlated with transcriptionally engaged enhancer elements, but …
Nascent RNA analyses: tracking transcription and its regulation
The programmes that direct an organism's development and maintenance are encoded in its
genome. Decoding of this information begins with regulated transcription of genomic DNA …
genome. Decoding of this information begins with regulated transcription of genomic DNA …
Widespread transcriptional pausing and elongation control at enhancers
T Henriques, BS Scruggs, MO Inouye… - Genes & …, 2018 - genesdev.cshlp.org
Regulation by gene-distal enhancers is critical for cell type-specific and condition-specific
patterns of gene expression. Thus, to understand the basis of gene activity in a given cell …
patterns of gene expression. Thus, to understand the basis of gene activity in a given cell …