Hallmarks of response, resistance, and toxicity to immune checkpoint blockade
G Morad, BA Helmink, P Sharma, JA Wargo - Cell, 2021 - cell.com
Unprecedented advances have been made in cancer treatment with the use of immune
checkpoint blockade (ICB). However, responses are limited to a subset of patients, and …
checkpoint blockade (ICB). However, responses are limited to a subset of patients, and …
The MYC oncogene — the grand orchestrator of cancer growth and immune evasion
R Dhanasekaran, A Deutzmann… - Nature reviews Clinical …, 2022 - nature.com
The MYC proto-oncogenes encode a family of transcription factors that are among the most
commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or …
commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or …
[HTML][HTML] Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments
S Kumagai, S Koyama, K Itahashi, T Tanegashima… - Cancer Cell, 2022 - cell.com
The balance of programmed death-1 (PD-1)-expressing CD8+ T cells and regulatory T
(Treg) cells in the tumor microenvironment (TME) determines the clinical efficacy of PD-1 …
(Treg) cells in the tumor microenvironment (TME) determines the clinical efficacy of PD-1 …
[HTML][HTML] Turning cold tumors into hot tumors by improving T-cell infiltration
YT Liu, ZJ Sun - Theranostics, 2021 - ncbi.nlm.nih.gov
Immunotherapy, represented by immune checkpoint inhibitors (ICIs), has greatly improved
the clinical efficacy of malignant tumor therapy. ICI-mediated antitumor responses depend …
the clinical efficacy of malignant tumor therapy. ICI-mediated antitumor responses depend …
Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential
X Xu, Q Peng, X Jiang, S Tan, Y Yang… - … & Molecular Medicine, 2023 - nature.com
Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …
Cooperation between constitutive and inducible chemokines enables T cell engraftment and immune attack in solid tumors
We investigated the role of chemokines in regulating T cell accumulation in solid tumors.
CCL5 and CXCL9 overexpression was associated with CD8+ T cell infiltration in solid …
CCL5 and CXCL9 overexpression was associated with CD8+ T cell infiltration in solid …
The multi-factorial nature of clinical multidrug resistance in cancer
Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …
The roles of DNA, RNA and histone methylation in ageing and cancer
Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins
and RNA. The methylation of chromatin components is highly conserved as it helps …
and RNA. The methylation of chromatin components is highly conserved as it helps …
Short-chain fatty acids in diseases
D Zhang, YP Jian, YN Zhang, Y Li, LT Gu… - Cell Communication and …, 2023 - Springer
Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation
of dietary fibre in the gastrointestinal tract. The absorption of SCFAs is mediated by substrate …
of dietary fibre in the gastrointestinal tract. The absorption of SCFAs is mediated by substrate …
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance
The ever-increasing understanding of the complexity of factors and regulatory layers that
contribute to immune evasion facilitates the development of immunotherapies. However, the …
contribute to immune evasion facilitates the development of immunotherapies. However, the …