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[HTML][HTML] hERG K+ channels: structure, function, and clinical significance
The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …
Ion channels as therapeutic targets: a drug discovery perspective
Ion channels are membrane proteins expressed in almost all living cells. The sequencing of
the human genome has identified more than 400 putative ion channels, but only a fraction of …
the human genome has identified more than 400 putative ion channels, but only a fraction of …
Human engineered heart tissue: analysis of contractile force
I Mannhardt, K Breckwoldt, D Letuffe-Brenière… - Stem cell reports, 2016 - cell.com
Analyzing contractile force, the most important and best understood function of
cardiomyocytes in vivo is not established in human induced pluripotent stem cell-derived …
cardiomyocytes in vivo is not established in human induced pluripotent stem cell-derived …
Molecular pathophysiology of congenital long QT syndrome
Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …
the fundamental cellular electrical event in the heart. The concerted function of these …
[PDF][PDF] K (+) channels: function-structural overview
Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …
action potential, controlling the membrane potential, modulating hormone secretion …
Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue
Jervell and Lange-Nielsen syndrome (JLNS) is one of the most severe life-threatening
cardiac arrhythmias. Patients display delayed cardiac repolarization, associated high risk of …
cardiac arrhythmias. Patients display delayed cardiac repolarization, associated high risk of …
Innovative approaches to anti-arrhythmic drug therapy
Normal cardiac function requires an appropriate and regular beating rate (cardiac rhythm).
When the heart rhythm is too fast or too slow, cardiac function can be impaired, with …
When the heart rhythm is too fast or too slow, cardiac function can be impaired, with …
Murine electrophysiological models of cardiac arrhythmogenesis
CLH Huang - Physiological reviews, 2017 - journals.physiology.org
Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …
processes underlying excitable activity and their tissue propagation as coherent wavefronts …
The hERG K+ channel: target and antitarget strategies in drug development
The human ether-à-go-go related gene (hERG) K+ channel is of great interest for both basic
researchers and clinicians because its blockade by drugs can lead to QT prolongation …
researchers and clinicians because its blockade by drugs can lead to QT prolongation …
Structure, function, and modification of the voltage sensor in voltage-gated ion channels
Voltage-gated ion channels are crucial for both neuronal and cardiac excitability. Decades
of research have begun to unravel the intriguing machinery behind voltage sensitivity …
of research have begun to unravel the intriguing machinery behind voltage sensitivity …