How can biophysical principles help precision medicine identify rare driver mutations? A
major tenet of pragmatic approaches to precision oncology and pharmacology is that driver …

Highlights•Global collaborative efforts are filling the pipeline of new antileishmanial
drugs.•Target and phenotypic assays are complementary in providing new first-in-class …

Aqueous solubility is an important physicochemical property of compounds in anti-cancer
drug discovery. Artificial intelligence solubility prediction tools have scored impressive …

Treatments against leishmaniasis are limited and the development of new molecules is
crucial. One class of developmental drug that has shown activity against the parasite …

Leishmaniasis is a group of neglected tropical diseases caused by at least 20 species of
Leishmania protozoa, which are spread by the bite of infected sandflies. There are three …

Leishmaniasis, a Neglected Tropical Parasitic Disease (NTPD), is induced by several
Leishmania species and is disseminated through sandfly (Lutzomyia longipalpis) bites. The …

Abstract The World Health Organization (WHO) classifies leishmaniasis as a disease for
which the development of new treatments is a priority. Available drugs are not fully effective …

Herein we report a series of antileishmanial analogues derived from 4-[(3, 5-dimethyl-4-
isoxazolyl) acetyl]-9-[(1-methyl-3-piperidinyl) methoxy]-7-(5-methyl-2-thienyl)-2, 3, 4, 5 …

Leishmaniasis, a neglected tropical disease caused by Leishmania species parasites,
annually affects over 1 million individuals worldwide. Treatment options for leishmaniasis …

Leishmaniasis is a neglected tropical disease that is estimated to afflict over 12 million
people. Current drugs for leishmaniasis suffer from serious deficiencies, including toxicity …