The study of biomolecules in their native environments is a challenging task because of the
vast complexity of cellular systems. Technologies developed in the last few years for the …

Biomoleküle in ihrer natürlichen Umgebung zu erforschen, ist wegen der enormen
Komplexität zellulärer Systeme eine anspruchsvolle Aufgabe. In den letzten Jahren …

Replicating the multi-hierarchical self-assembly of collagen has long-attracted scientists,
from both the perspective of the fundamental science of supramolecular chemistry and that …

In vivo incorporation of unnatural amino acids by amber codon suppression is limited by
release factor-1–mediated peptide chain termination. Orthogonal ribosome-mRNA pairs …

We report a method for site-specifically incorporating l-lysine derivatives into proteins in
mammalian cells, based on the expression of the pyrrolysyl-tRNA synthetase (PylRS) …

A suppressor tRNATyr and mutant tyrosyl‐tRNA synthetase (TyrRS) pair was developed to
incorporate 3‐iodo‐l‐tyrosine into proteins in mammalian cells. First, the Escherichia coli …

Chemical and biological diversity of protein structures and functions can be widely
expanded by position-specific incorporation of non-natural amino acids carrying a variety of …

▪ Abstract The genetic code is established by the aminoacylation of transfer RNA, reactions
in which each amino acid is linked to its cognate tRNA that, in turn, harbors the nucleotide …

Protein synthesis and its relation to the genetic code was for a long time a central issue in
biology. Rapid experimental progress throughout the past decade, crowned with the recently …

More than two decades ago a general method to genetically encode noncanonical or
unnatural amino acids (NAAs) with diverse physical, chemical, or biological properties in …