The study of biomolecules in their native environments is a challenging task because of the
vast complexity of cellular systems. Technologies developed in the last few years for the …

Molecular recognition, binding and catalysis are often mediated by non-covalent interactions
involving aromatic functional groups. Although the relative complexity of these so-called π …

This review describes a multidimensional treatment of molecular recognition phenomena
involving aromatic rings in chemical and biological systems. It summarizes new results …

The α7 nicotinic acetylcholine receptor plays critical roles in the central nervous system and
in the cholinergic inflammatory pathway. This ligand-gated ion channel assembles as a …

Noncovalent interactions are essential for the existence of solid and liquid phases. 1, 2
Traditionally touted as weak forces, quantification of these interactions, which govern the …

The chemistry community now recognizes the cation− π interaction as a major force for
molecular recognition, joining the hydrophobic effect, the hydrogen bond, and the ion pair in …

Nicotinic receptors—a family of ligand-gated ion channels that mediate the effects of the
neurotransmitter acetylcholine—are among the most well understood allosteric membrane …

Conspectus Supramolecular assembly is commonly driven by noncovalent interactions (eg,
hydrogen bonding, electrostatic, hydrophobic, and aromatic interactions) and plays a …

Nicotinic acetylcholine receptors are pentameric ion channels that mediate fast chemical
neurotransmission. The α3β4 nicotinic receptor subtype forms the principal relay between …

In proteins, the amino acids Phe, Tyr, and especially Trp are frequently involved in π
interactions such as π–π, cation− π, and CH− π bonds. These interactions are often crucial …