The global obesity epidemic and the growing elderly population largely contribute to the
increasing incidence of type 2 diabetes. Insulin resistance acts as a critical link between the …

The peptide hormone insulin is a key regulator of energy metabolism, proliferation and
survival. Binding of insulin to its receptor activates the PI3K/AKT signalling pathway, which …

Peroxiredoxins (PRDXs) are members of a highly conserved peroxidase family and maintain
intracellular reactive oxygen species (ROS) homeostasis. The family members are …

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is known as a tumor
suppressor gene that is frequently mutated in numerous human cancers and inherited …

Background Our previous work has shown peroxiredoxin-1 (PRDX1), one of major
antioxidant enzymes, to be a biomarker in human breast cancer. Hereby, we further …

Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are becoming
increasingly prevalent worldwide. Despite the different etiologies, their spectra and …

Extracellular vesicles (EVs) can be released from most cells in the body and act as
intercellular messengers transferring information in their cargo to affect cellular function. A …

We recently developed a novel keratin-derived protein (KDP) rich in cysteine, glycine, and
arginine, with the potential to alter tissue redox status and insulin sensitivity. The KDP was …

The glucose uptake in skeletal muscle is essential to produce energy through ATP, which is
needed by this organ to maintain vital functions. The impairment of glucose uptake …

We identified a novel mutant of Bombyx mori, designated as male-absent oily (genetic
symbol: om). The larval integument of this mutant is translucent due to a lack of uric acid in …