Health emerges from coordinated psychobiological processes powered by mitochondrial
energy transformation. But how do mitochondria regulate the multisystem responses that …

Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a
critical variable in human health and physiology, but its trajectory over the life course is …

To date, nutritional epidemiology has relied heavily on relatively weak methods including
simple observational designs and substandard measurements. Despite low internal validity …

Chronic psychosocial stress increases disease risk and mortality, but the underlying
mechanisms remain largely unclear. Here we outline an energy-based model for the …

Morning loaded calorie intake in humans has been advocated as a dietary strategy to
improve weight loss. This is also supported by animal studies suggesting time of eating can …

Understanding the impacts of activity on energy balance is crucial. Increasing levels of
activity may bring diminishing returns in energy expenditure because of compensatory …

Importance Short sleep duration has been recognized as a risk factor for obesity. Whether
extending sleep duration may mitigate this risk remains unknown. Objective To determine …

The prevailing notion that mitochondrial diseases arise from ATP deficiency is challenged by
recent evidence that oxidative phosphorylation defects trigger maladaptive stress responses …

Water is essential for survival, but one in three individuals worldwide (2.2 billion people)
lacks access to safe drinking water. Water intake requirements largely reflect water turnover …

Humans require energy to sustain their daily activities throughout their lives. This narrative
review aims to (a) summarize principles and methods for studying human energy …