Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …

In this work, we concentrate on the detection of anomalous behaviors in systems operating
in the physical world and for which it is usually not possible to have a complete set of all …

An RNA design algorithm takes a target RNA structure and finds a sequence that folds into
that structure. This is fundamentally important for engineering therapeutics using RNA …

A ribonucleic acid (RNA) sequence is a word over an alphabet on four elements {A, C, G, U}
called bases. RNA sequences fold into secondary structures where some bases pair with …

Nanotechnology and synthetic biology currently constitute one of the most innovative,
interdisciplinary fields of research, poised to radically transform society in the 21st century …

Motivation: RNAs play fundamental roles in cellular processes. The function of an RNA is
highly dependent on its 3D conformation, which is referred to as the RNA tertiary structure …

The development of algorithms for designing artificial RNA sequences that fold into specific
secondary structures has many potential biomedical and synthetic biology applications. To …

ABSTRACT RNA has become an integral building material in synthetic biology. Dominated
by their secondary structures, which can be computed efficiently, RNA molecules are …

Background The function of an RNA in cellular processes is directly related to its structure.
The free energy of RNA structure in another important key to its function as only some …

RNA inverse folding problem is a bioinformatics problem where the objective is to find an
RNA sequence that folds into a given target secondary structure. In this paper, we use …