Recent updates of diagnosis, pathophysiology, and treatment on osteoarthritis of the knee

S Jang, K Lee, JH Ju - International journal of molecular sciences, 2021 - mdpi.com
Osteoarthritis (OA) is a degenerative and chronic joint disease characterized by clinical
symptoms and distortion of joint tissues. It primarily damages joint cartilage, causing pain …

Osteoarthritis pain

H Yu, T Huang, WW Lu, L Tong, D Chen - International Journal of …, 2022 - mdpi.com
Joint pain is the hallmark symptom of osteoarthritis (OA) and the main reason for patients to
seek medical assistance. OA pain greatly contributes to functional limitations of joints and …

Gender-related aspects in osteoarthritis development and progression: a review

M Peshkova, A Lychagin, M Lipina, B Di Matteo… - International Journal of …, 2022 - mdpi.com
Osteoarthritis (OA) is a common degenerative joint disease treated mostly symptomatically
before approaching its definitive treatment, joint arthroplasty. The rapidly growing …

Human cartilage biomechanics: experimental and theoretical approaches towards the identification of mechanical properties in healthy and osteoarthritic conditions

E Belluzzi, S Todros, A Pozzuoli, P Ruggieri… - Processes, 2023 - mdpi.com
Articular cartilage is a complex connective tissue with the fundamental functions of load
bearing, shock absorption and lubrication in joints. However, traumatic events, aging and …

The role of fibrosis in osteoarthritis progression

YA Rim, JH Ju - Life, 2020 - mdpi.com
Osteoarthritis (OA) is a chronic degenerative joint disease where the main characteristics
include cartilage degeneration and synovial membrane inflammation. These changes in the …

The infrapatellar fat pad in inflammaging, knee joint health, and osteoarthritis

MG Wang, P Seale, D Furman - npj Aging, 2024 - nature.com
Osteoarthritis (OA) is the most common form of arthritis and accounts for nearly $140 billion
in annual healthcare expenditures only in the United States. Obesity, aging, and joint injury …

Knee osteoarthritis therapy: recent advances in intra-articular drug delivery systems

L Ma, X Zheng, R Lin, ARJ Sun, J Song… - Drug design …, 2023 - Taylor & Francis
Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their
poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a …

Infrapatellar fat pad-synovial membrane anatomo-fuctional unit: microscopic basis for Piezo1/2 mechanosensors involvement in osteoarthritis pain

A Emmi, E Stocco, R Boscolo-Berto… - Frontiers in Cell and …, 2022 - frontiersin.org
The Infrapatellar Fat Pad (IFP) is a fibro-adipose tissue of the knee recently reconsidered as
part of a single anatomo-functional unit (AFU) together with the synovial membrane (SM) …

[HTML][HTML] The biphasic role of the infrapatellar fat pad in osteoarthritis

S Yue, G Zhai, S Zhao, X Liang, Y Liu, X Chen… - Biomedicine & …, 2024 - Elsevier
Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration. It is
a whole organ disease characterized by cartilage degeneration and varying degrees of …

A bidirectional mendelian randomization study of sarcopenia-related traits and knee osteoarthritis

L Zhang, C Zhang, J Zhang, A Liu… - Clinical interventions in …, 2023 - Taylor & Francis
Background With the development of population aging worldwide, sarcopenia and knee
osteoarthritis (KOA), two age-related diseases, will continue to impose increasing medical …